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Invasive Cardiopulmonary Exercise Testing in Chronic Thromboembolic Pulmonary Disease; Obesity and the V/VCO Relationship.
J Clin Med
December 2024
Division of Cardiovascular Disease, Department of Medicine, Temple University Hospital, Philadelphia, PA 19140, USA.
: Invasive cardiopulmonary exercise testing (iCPET) provides valuable insight into dyspnea in patients with chronic thromboembolic pulmonary disease, in part through an increased relationship of minute ventilation to CO production (V/VCO). Obesity lowers the V/VCO in patients without cardiopulmonary disease; however, whether this holds true in obese subjects with chronic thromboembolic pulmonary hypertension (CTEPH) and chronic thromboembolic pulmonary disease (CTEPD) is unknown. : Report on the iCPET findings of patients with CTEPH and CTEPD and investigate the relationship between obesity and gas exchange parameters, especially V/VCO in these patients.
View Article and Find Full Text PDFGrowth Differentiation Factor 15 as a Biomarker for Risk Stratification in the Cardiothoracic Surgery Intensive Care Unit.
Biomolecules
December 2024
Department of Cardiology, Hospital de Santa Maria, Unidade Local de Saúde de Santa Maria, 1649-028 Lisbon, Portugal.
Growth Differentiation Factor 15 (GDF15) is an emerging biomarker that significantly increases during acute stress responses, such as infections, and is moderately elevated in chronic and inflammation-driven conditions. While evidence suggests that high levels of GDF15 in cardiac surgery are associated with worse outcomes, its utility as an evaluator of early postoperative complications remains unclear. This study aims to characterize the postoperative profile of GDF15 in patients undergoing isolated surgical aortic valve replacement, evaluating its association with short-term outcomes.
View Article and Find Full Text PDFGYY4137 ameliorates blood brain barrier damage by inhibiting autophagy mediated occludin degradation in cardiac arrest and resuscitation.
Sci Rep
January 2025
Department of Anesthesiology, Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Road, Nangang District, Harbin, 150086, Heilongjiang Province, China.
Cardiopulmonary resuscitation (CPR) after cardiac arrest (CA) is an important cause of neurological impairment and leads to considerable morbidity and mortality. The stability of the blood-brain barrier (BBB) is crucial for minimizing secondary neurological damage and improving long-term prognosis. However, the precise mechanisms and regulatory pathways that contribute to BBB dysfunction after CPR remain elusive.
View Article and Find Full Text PDFThe uses of right heart catheterization in cardio-pulmonary disease: State-of-the-art.
Am Heart J Plus
January 2025
Cardiology Division, NYU Langone Health and NYU School of Medicine, New York, NY, USA.
The right heart catheterization (RHC) remains an important diagnostic tool for a spectrum of cardiovascular disease processes including pulmonary hypertension (PH), shock, valvular heart disease, and unexplained dyspnea. While it gained widespread utilization after its introduction, the role of the RHC has evolved to provide valuable information for the management of advanced therapies in heart failure (HF) and cardiogenic shock (CS) to name a few. In this review, we provide a comprehensive overview on the indications, utilization, complications, interpretation, and calculations associated with RHC.
View Article and Find Full Text PDFExtracorporeal membrane oxygenation for Chinese neonates with severe respiratory and cardiac failure.
J Cardiothorac Surg
January 2025
Department of PICU of Pediatric Medicine, Seventh Medical Center, PLA General Hospital, Beijing, 100000, China.
Objective: We aimed to outline the experience with extracorporeal membrane oxygenation (ECMO) for respiratory and cardiac failure in neonates in our institution and compare our results with those from other countries.
Method: The clinical data of 28 neonates who required ECMO assistance were studied retrospectively.
Results: A total of 28 neonates underwent support with veno-arterial ECMO, including 14 cardiac support and 14 respiratory support.
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