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External oxidant-free alkylation of quinoline and pyridine derivatives. | LitMetric
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External oxidant-free alkylation of quinoline and pyridine derivatives.

Linhua Shen Xianying Gao Nannan Luan Zhenwei Liu Jingya Li Dapeng Zou Yangjie Wu Yusheng Wu

Org Biomol Chem

College of Chemistry, Green Catalysis Center, Zhengzhou University, Zhengzhou, People's Republic of China. and Tetranov Biopharm, LLC, and Collaborative Innovation Center of New Drug Research and Safety Evaluation, Zhengzhou, 450052, People's Republic of China and Tetranov International, Inc., 100 Jersey Avenue, Suite A340, New Brunswick, NJ 08901, USA.

Published: March 2020

A novel and efficient method for the generation of alkyl radicals and the alkylation of quinoline and pyridine derivatives under mild conditions has been developed. This strategy allows the direct alkylation of heteroaromatics in the absence of an external oxidant. A preliminary mechanistic study suggests that the present reaction probably proceeds via an intermolecular HAT process.

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 Source
http://dx.doi.org/10.1039/c9ob02653cDOI Listing

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