AI Article Synopsis
- Micelles, specifically cholesterol-conjugated polyoxyethylene sorbitol oleate (CPSO), are developed for targeted drug delivery of paclitaxel (PTX) to the lungs.
- The preparation involved a dialysis-ultrasonic method and optimization through experimental design, resulting in efficient encapsulation (78.48%) and drug loading (17.06%).
- Cell studies showed improved uptake in lung cells (A549) and effective evasion from macrophages, indicating potential for intravenous pulmonary targeting.
Article Abstract
Micelles are one of the most promising nanoplatforms for drug delivery, and here, cholesterol-conjugated polyoxyethylene sorbitol oleate (CPSO) micelles have been fabricated for the pulmonary delivery of paclitaxel (PTX). PTX-CPSO micelles were prepared by a dialysis-ultrasonic method, and a single-factor experiment with a Box-Behnken design was conducted to optimize the formulation. Furthermore, intracellular and phagocytosis escape studies of the optimized formulation were performed on A549 and NR8383 cells. The optimal micelles exhibited satisfactory encapsulation efficiency (78.48 ± 2.36%) and drug loading (17.06 ± 1.71%). studies showed enhanced CPSO micelle A549 cellular uptake and their ability to escape macrophages. PTX-CPSO micelles could be a promising system for pulmonary targeting by intravenous administration.
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| http://dx.doi.org/10.2217/nnm-2019-0376 | DOI Listing |
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