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Anti-Inflammatory, Anticancer (MCF-7, 3T3, and HeLa Cell Lines), and Brine Shrimp Lethality Assay and FTIR Analysis of the Extract and Fractions of the Whole Plant of . | LitMetric

AI Article Synopsis

  • * The whole-plant butanol fraction (WBFHE) demonstrated anti-inflammatory effects, while other extracts showed no such activity or anticancer properties against selected cell lines.
  • * FTIR analysis identified various functional groups related to compounds such as phenols, carboxylic acids, and alkanes, indicating the chemical composition of the plant extracts studied.

Article Abstract

In this study, anti-inflammatory, anticancer, brine shrimp lethality, and FTIR studies were evaluated. The oxidative burst assay using the chemiluminescence technique, MTT assay, brine shrimp lethality assay, and FTIR analysis were the methods used for the evaluation of anti-inflammatory, anticancer, brine shrimp lethality, and FTIR studies, respectively. The whole-plant butanol fraction of (WBFHE) showed anti-inflammatory activity on ROS having IC14.7 ± 2.5 while the extract and other fractions of the whole plant of exhibited no anti-inflammatory activity. None of the extract and fractions of the whole plant of exhibited anticancer (MCF-7, 3T3, and HeLa cell lines) activities. The whole-plant aqueous fraction of (WAFHE) and whole-plant butanol fraction of (WBFHE) showed lethality at high concentration while at low concentration, no toxicity was shown. The whole-plant methanolic extract of (WMEHE) and whole-plant n-hexane fraction of (WHFHE) exhibited no toxicity. FTIR interpretation showed the functional groups for the aromatic compounds, phenols, carboxylic acids, esters, alkanes, alkenes, alcohols, alkyl halides, sulfate esters, phosphines, silanes, nitriles, thiols, amines, phosphoric acids, and nitro compounds.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016474PMC
http://dx.doi.org/10.1155/2020/5056897DOI Listing

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