Objectives: To determine the clinical characteristics of methotrexate-associated lymphoproliferative disorder (MTX-LPD).
Methods: In this study, 12 RA patients who developed MTX-LPD were assessed. The peripheral blood lymphocyte (PBL) count at the onset of MTX-LPD was compared to that 6 months before the onset, in Epstein-Barr virus-encoded RNA (EBER)-positive and -negative subgroups. We examined the change in the PBL count after MTX withdrawal. In patients with relapsed LPD, changes in the PBL count before relapse were also examined.
Results: Regression of LPD after MTX withdrawal was noted in eight patients. In these patients, the PBL count was decreased at the onset of MTX-LPD compared to 6 months before the onset; the decrease was significantly more prominent in EBER-positive patients. In cases of spontaneous regression of LPD, the PBL count recovered quickly after MTX withdrawal. Four of eight patients showed a recurrence of LPD after they improved following MTX withdrawal. These patients also exhibited a decreased PBL count at recurrence compared to 6 months before recurrence.
Conclusion: A decrease in the PBL count might be involved in the pathogenesis of MTX-LPD, especially in EBER-positive cases and in patients with LPD relapse after MTX withdrawal following initial improvement.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1080/14397595.2020.1733246 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Soy Protein and Safflower-Seed Oil Attenuate Inflammation and Immune Dysfunction in Rats with Hyperuricemia.
Int J Mol Sci
December 2024
Department of Nutritional Science, Fu Jen Catholic University, New Taipei City 242062, Taiwan.
A plant-based diet is considered a promising approach for managing hyperuricemia (HUA). This study examined the effects of soy protein and plant-based oils on HUA-induced inflammation and immune dysfunction. Male Wistar rats, induced with HUA using oxonic acid and uric acid (UA), were fed casein or soy protein with palm or safflower oil (2 × 2 factorial design) for 8 weeks.
View Article and Find Full Text PDFBackground: Bovine leukaemia virus (BLV)-infected Holstein cattle carrying certain bovine leukocyte antigen (BoLA)-DRB3 alleles were previously shown to be resistant to BLV provirus multiplication, while those carrying other alleles were susceptible. This study aimed to determine whether the BoLA-DRB3 alleles carried by BLV-infected cattle could predict proviral load (PVL) and peripheral blood lymphocyte (PBL) count distribution (PVL/PBL distribution).
Methods: Blood samples from Holstein cattle on four dairy farms were tested for the presence of BLV antibodies using a commercial ELISA.
Technical note: Visual, rapid, scintillation point dosimetry for in vivo MV photon beam radiotherapy treatments.
Med Phys
August 2024
Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire, USA.
Background: While careful planning and pre-treatment checks are performed to ensure patient safety during external beam radiation therapy (EBRT), inevitable daily variations mean that in vivo dosimetry (IVD) is the only way to attain the true delivered dose. Several countries outside the US require daily IVD for quality assurance. However, elsewhere, the manual labor and time considerations of traditional in vivo dosimeters may be preventing frequent use of IVD in the clinic.
View Article and Find Full Text PDFDetermination of Whole Blood Loss From Minimally Invasive Myomectomy Using a Standardized Formula: A Pilot Study.
J Minim Invasive Gynecol
June 2024
Department of OB/GYN, David Geffen School of Medicine at UCLA, Los Angeles, California (Drs. Gigg, Goldrath, Havard, Parvataneni, Mehta, Chiang, Rodriguez, Fahey). Electronic address:
Study Objective: To determine the median perioperative blood loss (PBL) during minimally invasive surgical (MIS) myomectomy.
Design: Prospective pilot study.
Setting: Large academic teaching hospital.
Analysis of the expression and significance of lymphocyte ratio in different stages and clinical types of COVID-19.
Cell Mol Biol (Noisy-le-grand)
December 2023
Respiratory Department, Hebei Provincial People's Hospital, Shijiazhuang, Hebei 050051, China.
This study aimed to analyze the expression of lymphocyte ratio (LY%) in different stages and clinical staging of COVID-19 and explore the relationship between peripheral blood lymphocyte (PBL) ratio and COVID-19 severity to provide reference for early intervention. For this purpose, a total of 125 patients with COVID-19 admitted to Hebei Provincial People's Hospital from February 1, 2020, to March 1, 2022, were reviewed and divided into moderate, severe, and critical groups by the severity to analyze and compare peripheral lymphocyte ratios of patients with different clinical typing. Results showed that lymphocyte count, lymphocyte percentage, CD3+ T-lymphocyte count, CD4+ T-lymphocyte count, and CD8+ T-lymphocyte count all decreased gradually with increasing severity (F = 27.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!