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Double-blind randomised trial of saline solution for gargling and nasal rinsing in SARS-CoV-2 infection.

J Glob Health

December 2024

Department of Anesthesiology, Critical Care and Pain Medicine, UTHealth, Houston, Texas, USA.

Background: Previous studies have shown that hypertonic saline nasal irrigation and gargling reduced the duration of symptoms in upper respiratory infections caused by coronavirus. This study aims to investigate the effects of two saline regimens on symptoms associated with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2).

Methods: Between 2020 and 2022, individuals aged 18-65 years who tested positive for SARS-CoV-2 infection via polymerase chain reaction (PCR) were randomly assigned to either low- or high-saline regimens for 14 days.

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