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| http://dx.doi.org/10.1093/ecco-jcc/jjaa031 | DOI Listing |
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Multiomic analysis reveals cellular, transcriptomic and epigenetic changes in intestinal pouches of ulcerative colitis patients.
Nat Commun
January 2025
University of Chicago, Department of Medicine, Chicago, IL, USA.
Total proctocolectomy with ileal pouch anal anastomosis is the standard of care for patients with severe ulcerative colitis. We generated a cell-type-resolved transcriptional and epigenetic atlas of ileal pouches using scRNA-seq and scATAC-seq data from paired biopsy samples of the ileal pouch and the ileal segment above the pouch (pre-pouch) from patients (male=4, female=2), and paired biopsies of the terminal ileum and ascending colon from healthy individuals (male=3, female=3) serving as reference. Our study finds an additional population of absorptive and secretory epithelial cells within the pouch but not the pre-pouch.
View Article and Find Full Text PDFObjective: Evaluation of the effectiveness of vestibuloplasty according to microhemodynamics and oxygenation in the mucous membrane of the alveolar ridge.
Materials And Methods: To achieve this goal, a clinical and functional study was carried out in the mucous membrane of the alveolar ridge after vestibuloplasty in 80 patients (35 men and 45 women) aged from 18 to 65 years, average age 41.5±1.
The Study Aims: To evaluate and compare the growth of gingiva around dental implants following the use of collagen matrices and connective tissue grafts (CTG).
Materials And Methods: The study included 80 study participants, who were divided into four groups based on the type of material used to enhance gingival thickness. Two groups utilized collagen matrices, Fibro-Gide and FibroMatrix as materials, while the other two groups utilized CTG obtained from the hard palate or tubercle area of the maxilla as controls.
Objective: To analyze the dynamics of the condition of the mucous membrane in patients with metabolic syndrome at the stage of preparation for dental prosthetics using dental implants.
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Deciphering Pectin: A Comprehensive Overview of Its Origins, Processing, and Promising Utility.
ACS Omega
January 2025
Precision Livestock and Nutrition Unit, Gembloux Agro-Bio Tech, TERRA Teaching and Research Centre, Liège University, Passage des Déportés 2, Gembloux 4000, Belgium.
Pectin is an acidic heteropolysaccharide, a natural high molecular weight compound primarily found in higher plants. It consists of four major structural domains: homogalacturonan (HG), rhamnogalacturonan II (RG-II), rhamnogalacturonan I (RG-I), and xylogalacturonan (XGA). Various methods are currently employed for pectin extraction, including acid extraction, microbial fermentation, microwave-assisted extraction, and ion extraction, each with unique advantages and disadvantages.
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