Elephantiasic Pretibial Myxedema with Graves' Disease: Spontaneously Induced and Dramatically Resolved after Radioiodine Treatment.

Eur Thyroid J

Department of Nuclear Medicine, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.

Published: January 2020

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7024891PMC
http://dx.doi.org/10.1159/000504217DOI Listing

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Article Synopsis
  • Graves' dermopathy is a skin condition related to Graves' disease, highlighted by the buildup of glycosaminoglycans in the skin's deeper layers.
  • Most cases of pretibial myxedema resolve on their own, but some can cause significant damage.
  • Conventional treatment includes topical steroids, though intralesional steroids, like triamcinolone acetate, have shown effective results in some cases.
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Keck School of Medicine, University of Southern California, Los Angeles. Drs. Choi, Wysong, and Crew are from the Department of Dermatology. Dr. Christianakis is from the Department of Rheumatology.

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Successful therapeutic approach in a patient with elephantiasic pretibial myxedema.

An Bras Dermatol

August 2020

Graduate and Post-Graduate Program in Dermatology, Faculdade Suprema, Juiz de Fora, MG, Brazil.

Localized pretibial myxedema is a dermopathy whose treatment is a challenge in dermatology, occurring in 0.5-4% of patients with Graves' disease. This autoimmune thyroid condition stimulates the production of hyaluronic acid and glycosaminoglycans that are deposited particularly in the pretibial region.

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