Role of antibiotic envelopes in preventing cardiac implantable electronic device infection: A meta-analysis of 14 859 procedures.

Introduction: We conducted an updated meta-analysis assessing the role of antibiotic envelopes in preventing Cardiac implantable electronic devices (CIED)-related infections as compared to standard infection prevention strategies.

Methods: A systematic search was conducted on Medline/PubMed and EMBASE/Ovid database. We used Mantel-Haenszel method with fixed-effect model to compute risk ratio (RR) with 95% confidence interval (CI). We also performed subgroup and trial sequential analysis on the data.

Results: Antibiotic envelope reduced the risk of both all infections [RR: 0.41, CI: 0.31-0.54,  < .05,  = 75%,  < .05] and major infections [RR: 0.48, CI: 0.32-0.70,  < .05,  = 60%,  = .04].

Conclusion: Prophylactic use of antibiotic envelopes as an adjuvant therapy to standard infection prevention strategies, helps in reducing the risk of CIED infections.