Drug-in-hydroxypropyl-β-cyclodextrin-in-lipoid S100/cholesterol liposomes: Effect of the characteristics of essential oil components on their encapsulation and release. | LitMetric
Bioactive Molecules Research Laboratory, Doctoral School of Sciences and Technologies, Faculty of Sciences, Section II, Lebanese University, Lebanon.
Published: April 2020
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Article Abstract
Drug-in-cyclodextrin-in-liposome (DCL) represents a very promising approach for preserving essential oil (EO) components, thereby extending their shelf life and activity. In this study, we examined the effect of chemical structure, octanol/water partition coefficient (log P), and Henry's law constant (H) on the encapsulation and the release of monoterpenes (eucalyptol, pulegone, terpineol, and thymol) and phenylpropenes (estragole and isoeugenol) from DCLs. Hydroxypropyl-β-cyclodextrin/EO component (HP-β-CD/EO component) inclusion complexes were prepared in aqueous solution and loaded into liposomes by the ethanol injection method. The phospholipid:cholesterol:EO component molar ratio determined for DCL structures was affected by characteristics of EO components. The presence of a propenyl tail or a hydroxyl group in the structure of EO component may improve its loading into DCLs. Furthermore, low encapsulation efficiency (EE) was obtained for DCLs exhibiting high cholesterol membrane content. In addition, a positive linear relationship was found between the loading ratio of monoterpenes into DCLs and their hydrophobic character expressed as log P. The release of components from DCLs was influenced by their EE into the formulations. Finally, DCL formulations retain considerable amounts of EO components after 10 months.
Introduction: The plasma membrane-bound protein, multi-drug resistance-associated protein 4 (), has gained attention for its pivotal role in facilitating the efflux of a wide range of endogenous and xenobiotic molecules. Its significance in adipogenesis and fatty acid metabolism has been brought to light by recent studies. Notably, research on knockout ( ) mice has established a link between the absence of and the development of obesity and diabetes.
The present investigation "Effect of essential oils and chia seed () in fortification of pineapple jam." was conducted during the year 2022-2023 at the Post harvest laboratory of Horticulture Department, Sher-e-Bangla Agricultural University, Dhaka. The study investigated the effects of essential oil and chia seeds on the quality of pineapple jam.
Laboratory of Spectroscopy, Molecular Modelling, Materials, Nanomaterial, Water and Environment, CERNE2D, Mohammed V University in Rabat, Faculty of Science, Rabat, Morocco.
Introduction: Morocco is home to a remarkable diversity of flora, including several species from the Artemisia genus. This study aims to thoroughly examine the chemical composition of essential oils derived from Artemisia species and assess their antibacterial and antioxidant properties through in vitro experiments and in silico simulations.
Objective: Vitamin E, in the form of α-tocopherol (TOCO), is an essential lipophilic antioxidant widely used in topical formulations. However, incorporating pure TOCO into skincare products poses significant challenges due to its limited solubility and high sensitivity to heat, light and oxidation. The present cross-sectional study aimed to innovate by encapsulating TOCO using non-animal sustainable biopolymers through complex coacervation and to investigate the interaction of these coacervates with cosmetic emulsions, focusing on their impact on the emulsions' physicochemical properties and stability.
The manipulation of cultivation conditions in addition to environmental changes is a key factor affecting the growth, secondary metabolites production, and the biological activity of the plant. Our study aims to evaluate the impact of foliar spray of ethephon, water stress, organic and inorganic fertilizers on the cytotoxic and antimicrobial activities of the fruit oil of Foeniculum vulgare, Miller, var. dulce and its vegetative growth and oil composition.
