Porokeratosis (PK) consists of abnormal keratinization of the epidermis of uncertain etiology and was first described by Mibelli in 1893. Multiple clinical variants of porokeratosis are recognized. The following is a case of a young male who presented more than one form of PK simultaneously. The hallmark of PK is the cornoid lamella, which can be identified in histopathology, and sometimes, as in our case, dermoscopy examination is the clue for diagnosis. This condition is often misdiagnosed and, therefore, not appropriately treated. Several treatment options are available and each clinical form may respond better to a specific therapy. However, consistency in treatment guidelines is still lacking.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/dth.13274 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Porokeratosis ptychotropica: Case reports and literature review.
Ann Dermatol Venereol
December 2024
Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei, China. Electronic address:
Porokeratosis ptychotropica (PP) is a rare variant of porokeratosis that frequently mimics the clinical manifestations of various squamoproliferative disorders. It lacks a specific definition and adequate understanding. Diagnosis is difficult clinically and remains controversial in some published cases.
View Article and Find Full Text PDFPorokeratoses-A Rare Group of Dermatoses.
Medicina (Kaunas)
November 2024
Department of Dermatology, Institute of Medical Sciences, Medical College of Rzeszow University, 35010 Rzeszow, Poland.
Porokeratoses represent a rare group of skin diseases characterized by abnormal keratinization. The condition may have a genetic background and can be triggered by environmental factors, including UV exposure and infections. Several clinical variants of porokeratosis can be distinguished, including Mibelli's porokeratosis, disseminated superficial actinic porokeratosis, superficial disseminated porokeratosis, and porokeratosis palmaris plantaris et disseminata.
View Article and Find Full Text PDFMalignant Transformation in Porokeratosis Ptychotropica: A Systematic Review.
Acta Derm Venereol
October 2024
Department of Dermatology, National University Hospital, Singapore; Department of Medicine, National University of Singapore, Singapore.
Porokeratosis ptychotropica (PP) is a rare and unusual variant of porokeratosis. There is a dearth of information on the natural history, epidemiology, and optimal treatment options. This study aimed to characterize the worldwide distribution, epidemiology, clinical features, and treatments attempted for all reported cases of porokeratosis ptychotropica.
View Article and Find Full Text PDFA Clinico-Epidemiological Study on Porokeratosis.
Indian J Dermatol
August 2024
Department of Dermatology, Mysore Medical College and Research Institute, Mysore, Karnataka, India.
Article Synopsis
- Porokeratosis (PK) is a chronic skin condition that presents as elevated, hyperkeratotic papules or plaques with a distinct raised border, linked to mutations in the mevalonate kinase enzyme.
- The study involved 11 patients, mostly females, with Mibelli's type being the most common form observed; diagnostic techniques included clinical evaluation, dermoscopy indicating a double-marginated border, and histopathological examination showing the cornoid lamella.
- Regular monitoring is essential for early detection of potential malignant changes in PK variants, emphasizing the importance of using dermoscopy for non-invasive diagnosis.
MVD Variants Identified in a Rare Clinical Variant of Porokeratosis: A Case Report of Disseminated Superficial Porokeratosis (DSP) in a Chinese Patient.
Clin Cosmet Investig Dermatol
August 2024
Department of Dermatology, Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, Zhejiang, People's Republic of China.
Article Synopsis
- Porokeratosis includes various hereditary and acquired skin disorders that involve the abnormal growth of skin cells known as keratinocytes.
- These disorders show different symptoms but share a common feature in their tissue structure called the cornoid lamella.
- This study reveals a unique case of disseminated superficial porokeratosis linked to mutations in the MVD gene, enhancing our knowledge of its genetic causes and potential treatment options.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!