A broad choice of numerical schemes and methods currently exists for blood flow simulations. The results rely critically on the prescription of boundary conditions. The outflow boundary condition for a one-dimensional (1D) flow solver is usually prescribed via a Windkessel or lumped parameter model. The weakness of such an approach is the determination of the parameters. In the present work, we use an alternative approach, that is, a reflection coefficient (RC), to lumped parameter models for distal boundary conditions. With such a RC, the number of parameters required is reduced to one. We derive the theoretical foundation for the RC. Specifically, we couple a transmission line theory for peripheral resistance with a 1D arterial flow solver. We apply this method to a healthy and a stenosed virtual aorta, and show this method can reproduce some subtle features in arterial pressure propagation, such as the steepened pressure waveform and the reflection from the stenosed site. In summary, the RC parameter has strong physical implications in the theory of wave propagation and may be used in flow simulations where reflections need to be explicitly modeled. NOVELTY STATEMENT: A novel coupled one-dimensional-transimission line model has been developed in this work with detailed implementations. Only one outflow boundary condition, that is, the refection coefficient is required in the model. Reflections for a pulse wave from aortic terminals as well as from a stenotic site are numerically simulated.
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http://dx.doi.org/10.1002/cnm.3327 | DOI Listing |
Clin Kidney J
January 2025
Department of Nephrology, Beijing Friendship Hospital, Capital Medical University, Xicheng District, Beijing, China.
Background: Neurovascular coupling (NVC), as indicated by a comprehensive analysis of the amplitude of low-frequency fluctuation (ALFF) and cerebral blood flow (CBF), provides mechanistic insights into neurological disorders. Patients undergoing peritoneal dialysis (PD) and hemodialysis (HD) often face cognitive impairment, the causes of which are not fully understood.
Methods: ALFF was derived from functional magnetic resonance imaging, and CBF was quantified using arterial spin labeling in a cohort comprising 58 patients with PD, 60 patients with HD and 62 healthy controls.
Ophthalmol Sci
November 2024
Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida.
Purpose: When performed for clinically significant carotid artery stenosis (CAS), the long-term impact of carotid endarterectomy (CEA) on choroidal and choriocapillaris (CC) circulation was studied using swept-source OCT angiography.
Design: Prospective observational study.
Participants: Patients with clinically significant CAS undergoing unilateral CEA.
Crit Care Explor
January 2025
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University, Baltimore, MD.
Intermediate care (IC) is prevalent nationwide, but little is known about how to best organize this level of care. Using a 99-item cross-sectional survey assessing four domains (hospital and physical IC features, provider and nurse staffing, monitoring, and interventions/services), we describe the organizational heterogeneity of IC within a five-hospital healthcare system. Surveys were completed by nurse managers from 12 (86%) of 14 IC settings.
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March 2025
Department of Biology, Concordia University, Montreal, QC H4B 1R6, Canada.
Gene therapy targeting ischemic heart disease is a promising therapeutic avenue, but it is mostly restricted to viral-based delivery approaches which are limited due to off-target immunological responses. Focused ultrasound presents a non-viral, image-guided technique in which circulating intravascular microbubble contrast agents can reversibly enhance vascular permeability and gene penetration. Here, we explore the influence of flow rate on the microbubble-assisted delivery of miR-126, a potent pro-angiogenic biologic, using a custom acoustically coupled pressurized mesenteric artery model.
View Article and Find Full Text PDFEmerg Med Int
January 2025
Nanjing Comprehensive Stroke Center, Affiliated Nanjing Brain Hospital of Nanjing Medical University, Nanjing, China.
Ischemic stroke is one of the major emergency diseases leading to death and disability worldwide, characterized by its acute onset and the urgent need for prompt medical intervention to reduce mortality and long-term disability. Chronic terminal internal carotid artery and/or middle cerebral artery occlusion (CTI/MCAO) is an important subtype of intracranial artery occlusive disease. The superficial temporal artery-to-MCA (STA-MCA) bypass has been proposed to improve cerebral blood flow (CBF) and cerebrovascular reserve (CVR), potentially enhancing neurological outcomes.
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