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In total joint arthroplasty, periprosthetic joint infection (PJI) can be devastating. Corticosteroid injections (CSIs) are commonly administered for temporary pain relief in the setting of various conditions. Therefore, the current systematic review aims to evaluate whether CSIs administered prior to total shoulder arthroplasty (TSA) are a risk factor for PJI and revision surgery.
View Article and Find Full Text PDFProspective validation of ORACLE, a clonal expression biomarker associated with survival of patients with lung adenocarcinoma.
Nat Cancer
January 2025
Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.
Human tumors are diverse in their natural history and response to treatment, which in part results from genetic and transcriptomic heterogeneity. In clinical practice, single-site needle biopsies are used to sample this diversity, but cancer biomarkers may be confounded by spatiogenomic heterogeneity within individual tumors. Here we investigate clonally expressed genes as a solution to the sampling bias problem by analyzing multiregion whole-exome and RNA sequencing data for 450 tumor regions from 184 patients with lung adenocarcinoma in the TRACERx study.
View Article and Find Full Text PDF[Development of an e-learning training program for pharmacy technicians' authorization in non-sterile compounding unit.].
Ann Pharm Fr
January 2025
Service de Pharmacotechnie Pellegrin - CHU Bordeaux - Place Amélie Raba Léon 33000 Bordeaux, France.
Objectives : Training of pharmacy technicians in non-sterile compounding unit must meet the requirements of the French good manufacturing practices. Our current training program is composed of one week companionship preceded by a theoretical course and do not allow the acquisition of all the skills and knowledge required. The formation load over the pharmacist and technician also increase due to an important turnover among the technicians.
View Article and Find Full Text PDFStandardized Outcomes for Randomized Controlled Trials Targeting Early Interventions in Patients With Moderate-to-Severe Traumatic Brain Injury: Protocol for the Development of a Core Outcome Set.
JMIR Res Protoc
January 2025
INSERM, Methods in Patient-Centered Outcomes and Health Research, SPHERE, F-44000, Nantes Université, University of Tours, Nantes, France.
Background: : With more than 60 million new cases around the world each year, traumatic brain injury (TBI) causes substantial mortality and morbidity. Managing TBI is a major human, social, and economic concern. In the last 20 years, there has been an increase in clinical trials in neurocritical care, leading mostly to negative results.
View Article and Find Full Text PDFCurrent approach to diagnosis and management of low-phospholipid associated cholelithiasis syndrome.
Curr Opin Gastroenterol
January 2025
Reference Center for Inflammatory Biliary Diseases and Autoimmune Hepatitis, European Reference Network on Hepatological Diseases (ERN Rare-Liver), Saint-Antoine Hospital, Assistance Publique - Hôpitaux de Paris; Sorbonne University, INSERM, Saint-Antoine Research Center (CRSA).
Purpose Of Review: Low phospholipid-associated cholelithiasis (LPAC) syndrome is a rare genetic form of intrahepatic cholesterol lithiasis, affecting mainly young adults. This review describes the recent advances in genetic and clinical characterization, diagnosis and management of LPAC syndrome.
Recent Findings: Recent publications report data from several retrospective cohorts.
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