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Cardiovascular diseases (CVDs) remain one of the leading causes of morbidity and mortality worldwide. In recent years, the potential role of dietary interventions in preventing and managing CVDs has gained significant attention. Among these dietary components, walnuts ( L.
View Article and Find Full Text PDFBioinformatics and Deep Learning Approach to Discover Food-Derived Active Ingredients for Alzheimer's Disease Therapy.
Foods
January 2025
Department of Bioconvergence, Hoseo University, Asan 31499, Republic of Korea.
Alzheimer's disease (AD) prevention is a critical challenge for aging societies, necessitating the exploration of food ingredients and whole foods as potential therapeutic agents. This study aimed to identify natural compounds (NCs) with therapeutic potential in AD using an innovative bioinformatics-integrated deep neural analysis approach, combining computational predictions with molecular docking and in vitro experiments for comprehensive evaluation. We employed the bioinformatics-integrated deep neural analysis of NCs for Disease Discovery (BioDeepNat) application in the data collected from chemical databases.
View Article and Find Full Text PDFPhenolic Fractions from Walnut Milk Residue: Antioxidant Activity and Cytotoxic Potential.
Plants (Basel)
December 2024
Institute of Nutrition and Food Technology, University of Chile, El Líbano 5524, Macul, Santiago 7830490, Chile.
Walnut milk residues (WMR) were investigated for the first time through their phenolic characterization including soluble (free, esterified, and etherified) phenolics and those released from their insoluble-bound form (insoluble-bound phenolic hydrolysates, IBPHs) and their antioxidant properties. Free phenolics were recovered and alkaline or acid hydrolysis were used to recover the remaining phenolic fractions. Total phenolic compounds (TPCs) and their antioxidant activity were analyzed by Folin-Ciocalteu, FRAP, and ORAC methods, respectively.
View Article and Find Full Text PDFAncient structural variants control sex-specific flowering time morphs in walnuts and hickories.
Science
January 2025
Department of Evolution and Ecology, University of California, Davis, CA, USA.
Article Synopsis
- Balanced mating type polymorphisms provide insight into the evolution of sexual reproduction strategies in plants, particularly within the Juglandaceae family (like walnuts and hickories).
- Researchers have identified two distinct Mendelian inheritance mechanisms linked to ancient DNA polymorphisms that dictate whether flowers develop male or female first, showing a 1:1 genetic ratio.
- A dominant haplotype associated with female-first flowering is linked to a gene related to trehalose-6-phosphate metabolism, suggesting complex regulation of gene expression and hints at sex chromosome-like evolution in these plants.
Effects of leaf scorch on photosynthetic characteristics, fruit yield, and quality of walnuts.
Physiol Mol Biol Plants
December 2024
College of Forestry and Landscape Architecture, Xinjiang Agricultural University, Xinjiang, 830052 China.
The consequences of walnut ( L.) leaf scorch (WLS) were studied using the cultivated varieties, Wen185 ( 'Wen 185') and Xinxin2 ( 'Xinxin2') in the Aksu region, Xinjiang, China. Photosynthetic parameters and indoor chemical analysis were used to determine the variations in photosynthetic characteristics, osmotic regulatory substances, antioxidant enzyme activities, and changes in fruit yield and quality between diseased and healthy leaves.
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