Please verify if "pigtail guided" should be "pigtail catheter-guided": Recent design changes for left atrial appendage (LAA) closure devices have led to significant improvement by facilitating the procedural workflow (no need for pigtail guided LAA intubation), moving the workspace from distal LAA to the landing zone (closed distal end design), and improving device stability (different anchor design). The availability of different device types (plug vs disc-lobe design) offers an option to tailor a device type to a patient's anatomy; thereby, sealing results have improved substantially. The issue of device-related thrombus has not been resolved and deserves future research, with the goal of eliminating postprocedural antithrombotic medication without increasing risk for stroke.
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http://dx.doi.org/10.1016/j.ccep.2019.11.008 | DOI Listing |
BMC Plant Biol
December 2024
Center of Excellence in Genomics & Systems Biology (CEGSB) and Centre for Pre-breeding Research (CPBR), International Crops Research Institute for the Semi-Arid Tropics (ICRISAT), Hyderabad, 502324, India.
Pre-harvest sprouting (PHS) in groundnut leads to substantial yield losses and reduced seed quality, resulting in reduced market value of groundnuts. Breeding cultivars with 14-21 days of fresh seed dormancy (FSD) holds promise for precisely mitigating the yield and quality deterioration. In view of this, six multi-locus genome-wide association study (ML-GWAS) models alongside a single-locus GWAS (SL-GWAS) model were employed on a groundnut mini-core collection using multi season phenotyping and 58 K "Axiom_Arachis" array genotyping data.
View Article and Find Full Text PDFCurr Heart Fail Rep
December 2024
Department of General Internal Medicine and Psychosomatics, Heidelberg University Hospital, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.
Purpose Of Review: Heart failure (HF) is often accompanied by a constellation of comorbidities, leading to diverse patient presentations and clinical trajectories. While traditional methods have provided valuable insights into our understanding of HF, network medicine approaches seek to leverage these complex relationships by analyzing disease at a systems level. This review introduces the concepts of network medicine and explores the use of comorbidity networks to study HF and heart disease.
View Article and Find Full Text PDFAgeing Res Rev
December 2024
Department of Spine Surgery, Honghui Hospital, Xi'an Jiaotong University, Youyidong Road, Xi'an, Shaanxi, 710000, China; Shaanxi Key Laboratory of Spine Bionic Treatment, Xi'an, Shaanxi, 710000, China. Electronic address:
Current research primarily focuses on the pathological mechanisms of spinal cord injury (SCI), seeking to promote spinal cord repair and restore motorial and sensory functions by elucidating mechanisms of cell death or axonal regeneration. However, SCI is almost irreversible, and patients often struggle to regain mobility or self-care abilities after injuries. Consequently, there has been significant interest in modulating systemic symptoms following SCI to improve patients' quality of life.
View Article and Find Full Text PDFValue Health
December 2024
Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Australia, Queensland, Brisbane.
Objectives: Psychological distress is a state of emotional suffering and discomfort that often manifests as anxiety, depression, or other mental health symptoms, impairing daily functioning, and hindering concentration, relationships, and work or school performance. We aimed to examine the disutility associated with psychological distress.
Methods: We utilized longitudinal data obtained from the Household, Income and Labour Dynamics in Australia (HILDA) survey.
Nat Prod Res
December 2024
National Institute of Agronomic Research of Algeria, Station of Sidi Mehdi, Touggourt, Algeria.
Mushrooms have proven to be a valuable source of diverse bioactive compounds that can hold substantial potential for preventing and managing various diseases. This research focused on examining the numerous bioactive compounds found in () (Cooke & Massee) Priest mushrooms, particularly those obtained from ethyl acetate and dichloromethane extracts. Polyphenols, flavonoids, tannins, and alkaloids were also evaluated by chemical analysis.
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