: To investigate the effect of ozone and low-level laser (LLL) therapies on pain and function in patients with disc displacement with reduction.: Eighty temporomandibular joints were divided into four groups, namely ozone and laser treatment groups, and two placebo groups. Ozone and LLL therapies were applied over six sessions.: Pain on palpation scores demonstrated a statistically significant decrease over time in the treatment groups. Sham laser therapy only reduced the pain on palpation in temporomandibular joints; whereas, sham ozone only affected masseter muscle pain. The ozone treatment group demonstrated significantly better pressure pain threshold scores and mandibular movements than the other groups; however, pressure pain threshold scores of the masseter inferior were significantly higher in the laser group.: This study supports the use of ozone for pain reduction as an alternative treatment modality and LLL as a supportive therapy for temporomandibular disorders.
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