This article commemorates the life and contributions of one of the most influential sports surgeons in the history of orthopedic surgery, Dr. Robert Jackson.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6988619 | PMC |
http://dx.doi.org/10.1080/08998280.2019.1681815 | DOI Listing |
Background: Apolipoprotein E (APOE) is a known genetic risk factor for dementia. Midlife cardiovascular risk factors are associated with lower cognitive performance and increased dementia risk. However, little is known whether cardiovascular risk factors mediate or modify the associations between APOE and cognitive decline in late-life.
View Article and Find Full Text PDFBackground: There have been contradictory findings on the associations between lipids and cognitive decline, which could have been attributed to heterogeneity in APOE allele and sex.
Method: We analyzed a subset of the Chicago Health and Aging Project, comprising 3,496 biracial community-dwelling older adults (58% African American & 64% women; mean follow-up=4.6 years) with lipid panel and longitudinal cognitive tests.
Background: It is unclear whether inflammation, i.e., high interleukin-6 (IL-6) levels, and genetic risk, i.
View Article and Find Full Text PDFBackground: Late-Onset Alzheimer's Disease (LOAD) is characterized by genetic heterogeneity and there is no single model explaining the genetic mode of inheritance. To date, more than 70 genetic loci associated with AD have been identified but they explain only a small proportion of AD heritability. Structural variants (SVs) may explain some of the missing AD heritability, and specifically, their segregation in AD families has yet to be investigated.
View Article and Find Full Text PDFPhilos Trans R Soc Lond B Biol Sci
January 2025
Department of Genetics, Evolution and Environment, University College London, London WC1E 6BT, UK.
Anthropogenic climate change is projected to become a major driver of biodiversity loss, destabilizing the ecosystems on which human society depends. As the planet rapidly warms, the disruption of ecological interactions among populations, species and their environment, will likely drive positive feedback loops, accelerating the pace and magnitude of biodiversity losses. We propose that, even without invoking such amplifying feedback, biodiversity loss should increase nonlinearly with warming because of the non-uniform distribution of biodiversity.
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