AI Article Synopsis
- Boron nitride nanotubes (BNNTs) are gaining attention for their potential biomedical applications, particularly in imaging and tumor treatment.
- The incorporation of samarium and gadolinium into BNNTs was achieved through a reduction process involving their oxides and nitrogen/hydrogen gas at high temperatures.
- Characterization techniques and in vitro assays demonstrate that these modified BNNTs could serve as effective non-invasive imaging agents and enhance the treatment of various tumors.
Article Abstract
Boron nitride nanotubes (BNNTs) have been growing in notoriety in the development of systems aiming bioapplications. In this work we conducted an investigation about the mechanisms involved in the incorporation of samarium and gadolinium in BNNTs. The process was performed by the reduction of samarium and gadolinium oxides (SmO and GdO, respectively) in the presence of NH gas (witch decomposes into N and H) at high temperatures. Various characterization techniques were conducted to elucidate how Sm and Gd are introduced into the BNNT structure. Biological in vitro assays were performed with human fibroblasts and a human osteosarcoma cell line (SAOS-2). Our results show that the studied systems have high potential for biomedical application and can be used as non-invasive imaging agents, such as scintigraphy radiotracers or as magnetic resonance imaging (MRI) contrast medium, being able to promote the treatment of many types of tumors simultaneously to their diagnosis.
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| http://dx.doi.org/10.1016/j.apradiso.2019.109032 | DOI Listing |
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