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Anti-GAD65 musicogenic epilepsy: Bilateral and independent mesial temporal seizures revealed by foramen ovale electrodes.
Epilepsia Open
January 2025
Epilepsy Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
Musicogenic epilepsy (ME) is characterized by seizures triggered by music. The epileptogenic focus in this rare reflex epilepsy is often in the temporal lobe, although the precise localization is still unclear. A correlation between ME and the presence of GAD65 antibodies indicates a potential immunological pathogenic mechanism.
View Article and Find Full Text PDFAdvances in physiological and clinical relevance of hiPSC-derived brain models for precision medicine pipelines.
Front Cell Neurosci
January 2025
Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada.
Precision, or personalized, medicine aims to stratify patients based on variable pathogenic signatures to optimize the effectiveness of disease prevention and treatment. This approach is favorable in the context of brain disorders, which are often heterogeneous in their pathophysiological features, patterns of disease progression and treatment response, resulting in limited therapeutic standard-of-care. Here we highlight the transformative role that human induced pluripotent stem cell (hiPSC)-derived neural models are poised to play in advancing precision medicine for brain disorders, particularly emerging innovations that improve the relevance of hiPSC models to human physiology.
View Article and Find Full Text PDFis rarely associated with neurological manifestations. This report describes a rare case of endocarditis complicated by a cerebral stroke caused by . We also briefly reviewed the neurological clinical spectrum of disease described in the literature.
View Article and Find Full Text PDFRace Against the Clock: Severe Acute Abdominal Pain With Disastrous Complications.
Cureus
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Pulmonary, Critical Care and Sleep Medicine, University of New Mexico Hospitals, Albuquerque, USA.
Although a rare medical condition, gastric ischemia is a medical emergency and requires prompt recognition. Current literature review is scarce, with a primary focus on iatrogenic, surgical, and vascular etiologies. The cases discussed focus on hypoperfusion secondary to refractory shock as the etiology of gastric ischemia and, unfortunately, death.
View Article and Find Full Text PDFAnkylosing spondylitis (AS) is a chronic inflammatory disease affecting the axial skeleton, resulting in severe pain, decreased mobility, and irreversible structural damage. This study explores the evolving prevalence, patient demographics, and treatment trends for AS in the Korean population from 2010 to 2023, alongside advancements in targeted therapies. This population-based study utilized data from the National Health Insurance Database covering 2010 to 2023.
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