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The First Report of -1-Carrying , Isolated from a Clinical Sample in the North-East of Romania.
Microorganisms
November 2024
Department of Microbiology, Faculty of Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iași, Romania.
Colistin resistance poses a significant clinical challenge, particularly in Gram-negative bacteria. This study investigates the occurrence of plasmid-mediated colistin resistance among isolates (, , and spp.) and non-fermentative rods ( and ).
View Article and Find Full Text PDFCo-existence of two plasmids harboring transferable resistance-nodulation-division pump gene cluster, tmexCD1-toprJ1, and colistin resistance gene mcr-8 in Klebsiella pneumoniae.
Ann Clin Microbiol Antimicrob
July 2024
School of Laboratory Medicine and Bioengineering, Hangzhou Medical College, Hangzhou, China.
Background: The emergence of plasmid-mediated mobile colistin resistance (mcr) gene poses a great challenge to the clinical application of polymyxins. To date, mcr-1 to mcr-10 have been found in animals, humans, and the environment. Among them, mcr-8 was first identified in Klebsiella pneumoniae (K.
View Article and Find Full Text PDFGenomic analysis of carbapenem- and colistin-resistant Klebsiella pneumoniae complex harbouring mcr-8 and mcr-9 from individuals in Thailand.
Sci Rep
July 2024
Faculty of Public Health, Kasetsart University, Chalermphrakiat Sakon Nakhon Province Campus, Sakon Nakhon, Thailand.
Article Synopsis
- A recent study investigated the genomic features of mobile colistin-resistant genes (mcr) in carbapenem-resistant Enterobacterales (CRE) from clinical isolates collected between 2015 and 2020, focusing on K. pneumoniae and K. quasipneumoniae.
- The isolates were identified as K. pneumoniae (CRKP) ST147 carrying mcr-8 and K. quasipneumoniae (CRKQ) ST476 carrying mcr-9, both exhibiting significant resistance to colistin and including additional resistance genes.
- The findings underscore the necessity for enhanced surveillance and rational drug usage to combat the rising threat of mcr-carrying CRE.
Investigation of Plasmid-Mediated Colistin Resistance Genes (mcr-1-8) in Enterobacterales Isolates.
Cureus
June 2024
Department of Medical Microbiology, Afyonkarahisar Health Sciences University, Afyonkarahisar, TUR.
Article Synopsis
- The study highlights the growing threat of multidrug-resistant gram-negative bacteria, particularly carbapenem-resistant Enterobacterales (CRE), which are a major concern in hospital settings as they lead to severe infections.
- Colistin is often used as a last-resort treatment against CRE infections, but the rise of colistin-resistant strains complicates treatment options.
- The research involved analyzing 2,646 clinical Enterobacterales isolates, identifying 79 carbapenem-resistant ones, and further examining 27 of these for colistin resistance, finding that specific resistance genes were present in the colistin-resistant strains.
Co-transfer of IncFII/IncFIB and IncFII plasmids mediated by IS26 facilitates the transmission of mcr-8.1 and tmexCD1-toprJ1.
Ann Clin Microbiol Antimicrob
February 2024
Department of Clinical Laboratory, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No.9677 Jing-Shi Road, Jinan, 250021, Shandong, People's Republic of China.
Article Synopsis
- This study focused on the genomic characteristics of two clinical strains of Klebsiella pneumoniae, both of which are resistant to key antibiotics, colistin and tigecycline, and carry specific resistance genes (mcr-8.1 and tmexCD1-toprJ1).
- The strains, isolated from different patients, were analyzed using various methods like antimicrobial susceptibility testing, whole-genome sequencing, and bioinformatics to understand their resistance mechanisms and plasmid structures.
- Results showed that the strains displayed extensive multidrug resistance, with distinct plasmid structures facilitating gene transfer, indicating a concerning trend of antibiotic resistance driven by genetic rearrangements.
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