AI Article Synopsis
- - This study investigates the differences in prevalence and outcomes of surgically correctable congenital anomalies between males and females by conducting a systematic review based on PRISMA guidelines, analyzing data from 68 studies out of 42,722 identified.
- - It was found that males had significantly higher prevalence rates of 10 out of 14 congenital anomalies, such as Hirschsprung's disease and congenital diaphragmatic hernia, while females exhibited a higher prevalence of biliary anomalies like atresia and choledochal cyst.
- - The research concludes that males generally have higher rates of most congenital anomalies, suggesting the need for further studies to explore the embryological reasons behind these differences and their impact on health outcomes.
Article Abstract
Purpose: This study aims to compare the prevalence and outcomes of surgically correctable congenital anomalies between sexes.
Methods: Upon registration on PROSPERO (CRD42019120165), a librarian aided in conducting a systematic review using PRISMA guidelines. The five largest relevant studies were included for each anomaly. Cumulative prevalence differences and confidence intervals were calculated, and the Cochran-Mantel-Haenszel test was performed.
Results: Of 42,722 identified studies, 68 were included in our analysis. All included anomalies had greater than 1000 patients except duodenal atresia (n = 787) and intestinal duplication (n = 148). Males had a significantly higher prevalence than females in 10/14 anomalies (Hirschsprung's disease, omphalomesenteric duct, congenital diaphragmatic hernia, anorectal malformation, malrotation, esophageal atresia, congenital pulmonary airway malformation, intestinal atresia, omphalocele, and gastroschisis; p < 0.001). There was no difference in the prevalence of duodenal atresia or intestinal duplication between sexes (p = 0.88 and 0.65, respectively). Females had a significantly higher prevalence of biliary anomalies (atresia and choledochal cyst).
Conclusion: Our study indicates that males have higher prevalence rates of most congenital anomalies. Further investigations are required to illuminate the embryology underlying this sex distribution and whether sex influences outcomes.
Type Of Study: Systematic review and meta-analysis.
Level Of Evidence: Prognostic study, level II.
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Source |
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| http://dx.doi.org/10.1016/j.jpedsurg.2020.01.016 | DOI Listing |
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