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Hydrochlorothiazide Use and Risk of Skin Cancer: A Population-Based Retrospective Cohort Study.
Pharmacoepidemiol Drug Saf
November 2024
School of Pharmacy and Institute of Clinical Pharmacy and Pharmaceutical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Article Synopsis
- Hydrochlorothiazide (HCTZ) exposure has been linked to increased risks of squamous cell carcinoma (SCC) in white populations, but this study aims to compare skin cancer risks associated with HCTZ and other antihypertensive medications in an Asian population.
- Utilizing Taiwan's National Health Insurance Research Database, the study analyzed over 900,000 patients aged 20 and older who started antihypertensives between 2004 and 2015, focusing specifically on medication adherence for accurate risk evaluation.
- The results indicated no significant difference in basal cell carcinoma (BCC) risk between HCTZ and other antihypertensives, but there was a higher risk of SCC with HCTZ compared
MULTIPLE KERATINOCYTIC CANCERS AFTER INTAKE OF ANTIHYPERTENSIVES (LISINOPRIL/BISOPROLOL/HCT) AND ANTIARRHYTMICS (PROPAFENONE): THE IMPORTANT NEW LINKS TO THE NITROSO-CONTAMINATION AND THE METABOLIC REPROGRAMMING OF THE FUTURE CANCER CELL.
Georgian Med News
June 2024
3Department of Dermatology and Venereology, Military Medical Academy, Sofia, Bulgaria.
Article Synopsis
- The mechanisms behind the development of skin tumors are still not fully understood, particularly regarding the roles of photosensitivity and phototoxicity.
- Recent studies have linked specific nitrosamines, contaminants in common pharmaceuticals, to gene and phototoxicity in humans, raising concerns about their potential carcinogenic effects.
- Long-term use of contaminated medications may contribute to skin cancer risk by interfering with tumor suppressor genes and activating oncogenes, affecting overall cancer development.
Geographical Differences in Hydrochlorothiazide Associated Risk of Skin Cancer Balanced Against Disability Related to Hypertensive Heart Disease.
Am J Hypertens
October 2024
Department of Biomedicine, HEALTH, Aarhus University, Aarhus, Denmark.
Background: Hypertension affects 25%-30% of the world population. Hydrochlorothiazide (HCTZ) is among the most used and cheapest medications but was in 2018 labeled with a warning stating the increased risk of nonmelanoma skin cancer (NMSC). This study describes geographical differences in the association between HCTZ and NMSC from the perspective of hypertensive heart disease (HHD).
View Article and Find Full Text PDFThe association between hydrochlorothiazide use and non-melanoma skin cancer in kidney transplant recipients.
Clin Kidney J
May 2024
Department of Nephrology, Rabin Medical Center, Petah Tikva, Israel.
Article Synopsis
- A study analyzed the risk of skin cancer in kidney transplant recipients who were treated with hydrochlorothiazide (HCTZ), a common diuretic medication, between 2010 and 2015.
- Among 520 patients, those on HCTZ showed a significant increase in the risk of non-melanoma skin cancer, particularly basal cell carcinoma, during a follow-up period of nearly 10 years.
- The results indicate that kidney transplant patients taking HCTZ may benefit from more frequent skin checks by dermatologists, especially if they have higher exposure to sunlight.
Recalcitrant Hypocalcemia: Postsurgical Hypoparathyroidism Exacerbated by a Chyle Leak Treated With Octreotide.
AACE Clin Case Rep
January 2024
Division of Endocrinology, Diabetes and Metabolism, NYU Langone Health, New York, New York.
Background/objective: To report a case of recalcitrant post-surgical hypocalcemia caused by hypoparathyroidism complicated by a chyle leak and octreotide use.
Case Report: A man in his 60s with a 4-month history of voice changes, 10-pound weight loss, and a right-sided neck mass presented with difficulty breathing for 1 week. He had a right laryngeal/hypopharyngeal mass, which was biopsied.
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