Chlorsulfuron has been applied in wheat fields as a recognized herbicide worldwide, yet it was officially banned in China since 2014 for its soil persistence problem. On the basis of our previous research that 5-dimethylamino distinctively accelerated degradation rate in soils, a modified amino moiety () and monosubstituted amino group () were introduced onto the fifth position of the benzene ring in sulfonylurea structures, as well as heterocyclic amino substituents () to seek a suitable soil degradation rate during such an in situ crop rotation system. Referring to the biological data and AHAS inhibition and AHAS docking results, they turned out to be AHAS inhibitors with high potent herbicidal activities. The various influence on soil degradation rate along with crop safety indicated that different substituents on the fifth position have exerted an apparent impact. Their united study of structure-activity-safety-degradation relationship has great potential to provide valuable information for further development of eco-friendly agrochemicals.
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