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Cohort profile: the provincial opioid agonist treatment cohort in Ontario, Canada.
Eur J Epidemiol
January 2025
Health Sciences North Research Institute, Sudbury, ON, Canada.
Background: Opioid Agonist Treatment (OAT) is the most effective intervention for opioid use disorder (OUD), but retention has decreased due to increasingly potent drugs like fentanyl. This cohort can be used retrospectively to observe trends in service utilization, healthcare integration, healthcare costs and patient outcomes. It also facilitates the design of observational studies to mimic a prospective design.
View Article and Find Full Text PDFWhat substance use services are advertised by local governments? An analysis of data from county websites in New York state.
Public Health
January 2025
Department of Public Health Policy and Management, School of Global Public Health, New York University, 726 Broadway, New York, NY, 10012, United States.
Objective: To assess the substance use disorder (SUD) prevention and response activities that county governments in New York advertise.
Study Design: Cross-sectional study.
Methods: We coded websites of county public health, mental health, emergency, and social service departments to identify whether any government agency provided information about ten evidence-based SUD services.
Introduction: Mu-opioid receptors (MORs) are G-coupled protein receptors with a high affinity for both endogenous and exogenous opioids. MORs are widely expressed in the central nervous system (CNS), peripheral organs, and the immune system. They mediate pain and reward and have been implicated in the pathophysiology of opioid, cocaine, and other substance use disorders.
View Article and Find Full Text PDFPrehospital Buprenorphine in Treating Symptoms of Opioid Withdrawal - A Descriptive Review of the First 131 Cases in San Francisco, CA.
Prehosp Emerg Care
January 2025
EMS Bridge, Public Health Institute, Oakland, California.
Objectives: Opioid use disorder (OUD) remains a common cause of overdose and mortality in the United States. Emergency medical services (EMS) clinicians often interact with patients with OUD, including during or shortly after an overdose. The aim of this study was to describe the characteristics and outcomes of patients receiving prehospital buprenorphine for the treatment of opioid withdrawal in an urban EMS system.
View Article and Find Full Text PDFPrecipitated Withdrawal Induced by Prehospital Naloxone Administration.
Prehosp Emerg Care
January 2025
Department of Emergency Medicine, College of Medicine, The University of Arizona, Tucson, Arizona.
Objectives: Buprenorphine is becoming a key component of prehospital management of opioid use disorder. It is unclear how many prehospital patients might be eligible for buprenorphine induction, as traditional induction requires that patients first have some degree of opioid withdrawal. The primary aim of this study was to quantify how many patients developed precipitated withdrawal after receiving prehospital naloxone for suspected overdose, as they could be candidates for prehospital buprenorphine.
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