AI Article Synopsis
- Long non-coding RNAs (lncRNAs) play important roles in cancer, with LOXL1-AS1 identified as a pro-oncogene in various tumors, particularly ovarian cancer.
- The study finds that LOXL1-AS1 is highly expressed in ovarian cancer tissue compared to adjacent non-cancerous tissue and interacts with miR-18b-5p and its target gene, VMA21.
- Results show that silencing LOXL1-AS1 or mimicking miR-18b-5p inhibits ovarian cancer cell growth and aggressiveness, indicating that LOXL1-AS1 promotes cancer cell proliferation and metastasis through a miR-18b-5p/VMA21 pathway.
Article Abstract
Long non-coding RNAs (lncRNAs) exert critical effects in the process of malignant cancers and lncRNA LOXL1 Antisense RNA 1 (LOXL1-AS1) has been demonstrated to be a pro-oncogene in multiple tumor types. In the current study, we illuminated the precise roles of LOXL1-AS1 in the development of ovarian cancer. LOXL1-AS1 is significantly overexpressed in ovarian carcinoma tissue compared with adjacent non-cancerous sample. The luciferase reporter gene assay reveals the relationship between LOXL1-AS1 and miR-18b-5p, miR-18b-5p and its target gene, Vacuolar ATPase Assembly Factor VMA21 (VMA21). Transfection of LOXL1-AS1 siRNA or miR-18b-5p mimics inhibits the growth and aggressive phenotypes of SKOV3 and OVCAR3 cell. Furthermore, miR-18b-5p suppresses ovarian carcinoma cell proliferation and metastasis by targeting VMA21 and LOXL1-AS1 regulates ovarian carcinoma cell growth and metastasis through sponging miR-18b-5p. These findings suggest that lncRNA LOXL1-AS1 promotes ovarian cancer cell growth, migratory and invasiveness via modulating miR-18b-5p/VMA21 axis.
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| http://dx.doi.org/10.1016/j.biopha.2019.109568 | DOI Listing |
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