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Effect of high trimline aligners on distalizing mandibular molars: a three-dimensional finite element study.
Eur J Med Res
December 2024
Urumql DW Innovation InfoTech Co., Ltd., Xinjiang, China.
Objective: The primary focus of this investigation was to evaluate the biomechanical effects of high trimline design aligners on the distalization of mandibular molars, employing three-dimensional finite element analysis (3D-FEA). The study concentrated on aspects such as tooth movement, stress distribution, and anchorage control.
Methods: Utilizing Cone-beam computed tomography (CBCT) data, a detailed 3D geometrical model was constructed for finite element analysis.
A nomogram to distinguish noncardiac chest pain based on cardiopulmonary exercise testing in cardiology clinic.
BMC Med Inform Decis Mak
December 2024
Department of Cardiology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.
Background: Psychological disorders, such as anxiety and depression, are considered to be one of the causes of noncardiac chest pain (NCCP). And these patients can be challenging to differentiate from coronary artery disease (CAD), leading to a considerable number of patients still undergoing angiography. We aim to develop a practical prediction model and nomogram using cardiopulmonary exercise testing (CPET), to help identify these patients.
View Article and Find Full Text PDFFractional erbium-doped yttrium aluminum garnet laser-assisted drug delivery: impact of triamcinolone acetonide formulation on drug permeation.
Drug Deliv Transl Res
December 2024
Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Wanglang Road, Bangkoknoi, Bangkok, 10700, Thailand.
Ablative fractional laser-assisted drug delivery has gained attention as a promising method for enhancing dermal drug absorption and improving therapeutic outcomes in dermatological conditions, particularly for hypertrophic and keloid scars. However, despite the growing number of clinical trials and case reports supporting its efficacy, there remains a scarcity of robust evidence on the topical bioavailability and dermato-pharmacokinetics of drugs in human subjects. This study aimed to examine the enhancement of triamcinolone acetonide (TAC) bioavailability following treatment with a fractional Erbium-Doped Yttrium Aluminum Garnet (Er: YAG) laser.
View Article and Find Full Text PDFThe Train: A Supply of Inspiration for Delivering High-Quality Cancer Care.
Ann Surg Oncol
December 2024
Antoni van Leeuwenhoek, Amsterdam, The Netherlands.
Background: The past 10 years have convincingly shown that the TRAIN-studies, with their starting point in Antoni van Leeuwenhoek (Amsterdam), have proved their significance for breast cancer patients with stage II or III human epidermal growth factor receptor 2 (HER2)-positive breast cancer. The main aim of these studies is to maximize a positive, clinically relevant outcome with the least burdensome neoadjuvant systemic treatment option after which surgery and systemic treatment (in accordance with the current oncology guidelines) is provided.
Rationale And Conclusions: The breast cancer train studies give rise to plenty of ideas for optimization of treatment in oncology, which is in the best interest of the patient, the treating doctor or caregiver, and society.
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