Automated production of an fluorine-18 labeled tryptophan analogue, 1-(2-[F]fluoroethyl)-l-tryptophan (1-L-[F]FETrp) in a current Good Manufacturing Practice facility was achieved. 1-L-[F]FETrp was produced by a one-pot, two-step strategy with an overall synthesis time of approximately 100 min, a radiochemical yield of 20 ± 5% (decay corrected), radiochemical purity and enantiomeric excess over 90%, and a molar activity of 103 ± 15 GBq/μmol at the end of synthesis (EOS). The dose mass of 1-L-FETrp in four consecutive batches was less than 5 μg. The radiopharmaceutical product met all quality control criteria for clinical use.
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