AI Article Synopsis
- The study developed a PBPK model to analyze how cyclosporine A (CsA) is processed in Asian children with renal impairment (RI), using the Simcyp Simulator for improved accuracy.
- By adjusting physiological parameters based on differences between healthy and RI populations, researchers verified the model using data from Korean children with kidney disease who received multiple doses of CsA.
- The results indicated that the impact of renal impairment on drug pharmacokinetics is more significant in children compared to adults, allowing for a better understanding of how ethnicity, age, and renal function influence drug processing in specific populations.
Article Abstract
This study aimed to assess the pharmacokinetics of cyclosporine A (CsA) in Asian children with renal impairment (RI) by developing a physiologically-based pharmacokinetic (PBPK) model with Simcyp Simulator. The PBPK model of Asian children with RI was developed by modifying the physiological parameters of the built-in population libraries in Simcyp Simulator. The ratio of healthy and RI populations was obtained for each parameter showing a difference between the populations. Each ratio was multiplied by the corresponding parameter in healthy Asian children. The model verification was performed with published data of Korean children with kidney disease given multiple CsA administrations. Simulations were performed with different combinations of ethnicity, age, and renal function to identify the net impact of each factor. The simulated results suggested that the effect of RI was higher in children than adults for both Caucasian and Asian. In conclusion, the constructed model adequately characterized CsA pharmacokinetics in Korean children with RI. Simulations with populations categorized by ethnicity, age, and renal function enabled to assess the net impact of each factor on specific populations.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6989237 | PMC |
| http://dx.doi.org/10.12793/tcp.2019.27.3.107 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
ICMR-MDRF Diabetes Biosamples: Cohort profile.
Indian J Med Res
November 2024
Department of Diabetology, Madras Diabetes Research Foundation & Dr.Mohan's Diabetes Specialities Centre, Chennai, Tamil Nadu, India.
Background & objectives Biobanks are crucial for biomedical research, enabling new treatments and medical advancements. The biobank at the Madras Diabetes Research Foundation (MDRF) aims to gather, process, store, and distribute biospecimens to assist scientific studies. Methods This article details the profile of two cohorts: the Indian Council of Medical Research-India Diabetes (ICMR-INDIAB) study and the Registry of people with diabetes in India with young age at onset (ICMR-YDR).
View Article and Find Full Text PDFEffectiveness of various atropine concentrations in myopia control for Asian children: a network meta-analysis.
Front Pharmacol
December 2024
Shenzhen Eye Institute, Shenzhen Eye Hospital, Jinan University, Shenzhen, Guangdong, China.
Objectives: To assess the effectiveness of various atropine concentrations in managing myopia among children in East, South, and Southeast Asia, and to determine the most effective concentration.
Methods: A systematic literature review was conducted using PubMed, Web of Science, Cochrane Library, and EMBASE. The search was limited to articles published up to 1 June 2024, and included studies in Chinese or English.
Validation of the I- and D-type epistemic curiosity scale among young Chinese children and implications on early curiosity nurture.
BMC Psychol
December 2024
Faculty of Psychology, Southwest University, No.2 TianSheng Road, Beibei District, Chongqing, 400715, China.
Curiosity, an innate and intrinsic motivation to explore, makes vital contributions to learning in individuals of various ages. Epistemic curiosity centers on the drive to close information gaps and can be classified into joyous exploration and interest (I) and deprivation sensitivity (D) types. Each subtype is associated with different academic achievements, personality traits, emotions, and aspects of creativity.
View Article and Find Full Text PDFAdherence to introduction of iron-rich solid foods recommendations for infants: an analysis of Canadian Community Health Survey data using cycles 2015-2018.
J Nutr
December 2024
Centre for Population Health Data, Statistics Canada, Ottawa, Ontario K1A 0K9.
Background: Globally, guidelines on the introduction of solid foods to a breastfed infant's diet emphasize the importance of iron-rich foods.
Objective: The objective of this study is to report on adherence to Nutrition for Healthy Term Infants (NHTI) guidance on introduction of iron-rich solid foods first in infants living in Canada; and to explore factors associated with adherence using disaggregated data.
Methods: Nationally representative cross-sectional data from the Canadian Community Health Survey annual cycles 2015-2018 from biological mothers delivering an infant in the past 5 years were used (n=7253).
Diversity-Related, Student-Led National Medical Organizations: Leadership Opportunities for Learners.
MedEdPORTAL
December 2024
Dean, Universidad Central Del Caribe, School of Medicine; Executive Director, Latino Medical Student Association.
Introduction: In light of the lack of diversity in academic medicine leadership, diversity-related, student-led national medical organizations (NMOs) provide a space for solace and reprieve among common peers while providing an opportunity to develop leadership competencies in a supportive environment. Despite the impact NMOs have had on cultivating generations of leaders in medicine, trainees may not identify opportunities for leadership development that are transferable to future careers in academic medicine.
Methods: We designed and implemented a dynamic 60-minute workshop with an interactive PowerPoint presentation, author-owned video testimonials (from past student leaders of NMOs), two case presentations, and reflection exercises.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!