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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7001401PMC
http://dx.doi.org/10.4103/idoj.IDOJ_166_19DOI Listing

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Article Synopsis
  • Acrodermatitis enteropathica (AE) is a rare disorder that can either be inherited from birth or develop later, characterized by symptoms like skin inflammation around the mouth, diarrhea, skin issues on the extremities, and hair loss.
  • The report emphasizes the importance of considering AE as a potential diagnosis in older patients who display mucosal infections or ulcers.
  • It details the case of a 68-year-old woman with advanced liver disease who, after a fall resulting in a hip fracture, was found to have persistent mucosal ulcers upon hospital admission.
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Poorly controlled and long-standing hidradenitis suppurativa (HS) increases the risk of squamous cell carcinoma (SCC). We report a 54-year-old woman with an over 20-year history of HS, who had previously undergone wide perineal excision with secondary intention healing and presented with a painful verrucous vulvar plaque and proximal non-healing perineal wound. The patient had four perineal scouting biopsies performed and excisional biopsy with no evidence of high-grade dysplasia or carcinoma on histology.

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Dermatological conditions are more common and can present atypically, in human immunodeficiency virus-infected individuals. This case report describes a 22-year-old human immunodeficiency virus-positive Caucasian female who presented with a vulval lesion eight weeks after starting antiretroviral treatment. Clinical examination revealed a 2 cm well-demarcated plaque on the outer aspect of the left labium minus.

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Extramammary Paget's disease is a rare cutaneous, intraepithelial adenocarcinoma involving primarily the epidermis but occasionally extending into the underlying dermis. The condition typically presents as a red, velvety, pruritic skin rash of the vulva region which closely mimics a multitude of other, more common conditions. As a result, vulvar Paget's disease is frequently misdiagnosed, leading to an often lengthy lag time (an average of about 2-3 years) between the onset of symptoms and diagnosis.

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