AI Article Synopsis
- Modern society's 24/7 lifestyle creates a disconnect between our natural body rhythms and environmental cycles, adversely affecting health over time.
- Research on mice subjected to chronic circadian misalignment revealed higher rates of early mortality and significant changes in immune system-related gene pathways in their liver and kidneys.
- The study suggests that this long-term misalignment worsens immune aging and chronic inflammation, highlighting the importance of maintaining immune balance to combat health issues linked to disrupted circadian rhythms.
Article Abstract
Modern society characterized by a 24/7 lifestyle leads to misalignment between environmental cycles and endogenous circadian rhythms. Persisting circadian misalignment leads to deleterious effects on health and healthspan. However, the underlying mechanism remains not fully understood. Here, we subjected adult, wild-type mice to distinct chronic jet-lag paradigms, which showed that long-term circadian misalignment induced significant early mortality. Non-biased RNA sequencing analysis using liver and kidney showed marked activation of gene regulatory pathways associated with the immune system and immune disease in both organs. In accordance, we observed enhanced steatohepatitis with infiltration of inflammatory cells. The investigation of senescence-associated immune cell subsets from the spleens and mesenteric lymph nodes revealed an increase in PD-1CD44 CD4 T cells as well as CD95GL7 germinal center B cells, indicating that the long-term circadian misalignment exacerbates immune senescence and consequent chronic inflammation. Our results underscore immune homeostasis as a pivotal interventional target against clock-related disorders.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7018741 | PMC |
| http://dx.doi.org/10.1038/s41598-020-59541-y | DOI Listing |
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