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Deprescribing Antidepressants in Children and Adolescents: A Systematic Review of Discontinuation Approaches, Cross-Titration, and Withdrawal Symptoms.
J Child Adolesc Psychopharmacol
October 2024
Department of Psychiatry & Behavioral Neuroscience, College of Medicine, University of Cincinnati, Cincinnati, Ohio, USA.
Antidepressant medications, including selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs), are commonly used to treat depressive, anxiety, and obsessive-compulsive disorders in youth. Yet, data on discontinuing these medications, withdrawal symptoms, and strategies to switch between them are limited. We searched PubMed and ClinicalTrials.
View Article and Find Full Text PDFEffective Laboratory Diagnosis of Parasitic Infections of the Gastrointestinal Tract: Where, When, How, and What Should We Look For?
Diagnostics (Basel)
September 2024
Department of Biomedical Sciences, Faculty of Medicine, Collegium Medicum, Cardinal Stefan Wyszynski University, ul. Wóycickiego 1/3, 01-938 Warsaw, Poland.
Article Synopsis
- Gastrointestinal parasites (GIPs) are prevalent worldwide and challenging to diagnose due to lack of distinct symptoms linking them to specific diseases.
- A review of medical literature using various search phrases revealed that accurate diagnosis involves detecting parasites and understanding their connection to disease, taking into account potential multiple infections in patients.
- Emphasis is placed on interpreting lab results accurately, considering local epidemiology, and collecting appropriate samples (like feces or blood) at the right times for effective diagnosis and treatment monitoring.
Numerous studies have shown that childhood interventions can foster improved outcomes in adulthood. Less well understood is precisely how-that is, through which developmental pathways-these interventions work. This study assesses mechanisms by which the Fast Track project (n = 891), a randomized intervention in the early 1990s for high-risk children in four communities (Durham, NC; Nashville, TN; rural PA; and Seattle, WA), reduced delinquency, arrests, and general and mental health service utilization in adolescence through young adulthood (ages 12-20).
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