AI Article Synopsis

  • The study investigates the differences in cytokine profiles of the vitreous fluid in eyes with epiretinal membrane, distinguishing between those with and without an ectopic inner foveal layer (EIFL).
  • A total of 60 eyes were analyzed, revealing that eyes with EIFL had worse visual acuity, increased central foveal thickness, and higher levels of specific cytokines (CD163 and macrophage colony-stimulating factor) compared to those without EIFL.
  • The results suggest that the presence of EIFL is associated with higher levels of M2 macrophage markers, indicating that these cells may play a role in glial cell proliferation and the formation of EIFL.

Article Abstract

Purpose: To analyze the differences in the vitreous cytokine profiles in epiretinal membrane eyes with and without an ectopic inner foveal layer (EIFL).

Methods: Sixty eyes with epiretinal membrane (32 eyes without EIFL and 28 eyes with EIFL) were included. The vitreous samples were collected during surgery for epiretinal membrane. The cytokine levels of the vitreous were measured using a multiplex bead analysis.

Results: The mean logMAR visual acuity was worse (0.42 vs. 0.37; P = 0.331) and the central foveal thickness was higher in the EIFL group (496.9 µm vs. 434.2 µm; P = 0.007) than they were in the group without EIFL. The mean EIFL thickness was 164.1 ± 67.7 µm in the EIFL group. On multiplex analysis of the vitreous cytokines, the levels of CD163 (21529 pg/dL vs. 10877 pg/dL; P = 0.002) and macrophage colony-stimulating factor (206 pg/dL vs. 159 pg/dL, P = 0.004) were significantly higher in the EIFL group than they were in the group without EIFL.

Conclusions: Eyes with EIFL had increased vitreous levels of M2 macrophage markers. The activation of glial cell proliferation by M2 macrophages may contribute to EIFL formation.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326506PMC
http://dx.doi.org/10.1167/iovs.61.2.19DOI Listing

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