Demand for vascular access devices to meet the clinical needs of patients has increased dramatically in recent years, with a disproportionate increase in the numbers of individuals requiring a central venous access device (CVAD). With this increasing number of patients becoming recipients of CVADs globally each year, the associated incidence of catheter-related bloodstream infections (CRBSIs) is also increasing. In addition, there is strong evidence to demonstrate that antimicrobial resistance is a global challenge. There is a need to change the approach to CVAD management and get back to basics through a clearer understanding of how the incidence of CRBSIs can be reduced. This includes the role of biofilm and how its development can be inhibited through the use of an effective lock solution, and the avoidance of antibiotics.
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http://dx.doi.org/10.12968/bjon.2020.29.3.S25 | DOI Listing |
Antibiotics (Basel)
January 2025
Unit II, Department of Infectious Diseases, Luigi Sacco Hospital, ASST Fatebenefratelli Sacco, 20157 Milan, Italy.
: Vascular access device (VAD)-associated infections, including catheter-related (CRBSI) and catheter-associated bloodstream infections (CABSI), present significant challenges in patient care. While multidisciplinary VAD teams (VATs) are equipped with protocols for managing these infections, adherence to these guidelines in real-life practice is inconsistent. This study aims to evaluate the alignment between actual VAD infection management practices and VAT-recommended protocols.
View Article and Find Full Text PDFRev Med Chil
September 2024
Unidad de Diálisis Peritoneal, Departamento de Nefrología, Pontificia Universidad Católica de Chile, Santiago, Chile.
Fungal peritonitis is a rare complication associated with peritoneal dialysis, whose standard management consists of systemic antifungal therapy associated with early removal of the peritoneal dialysis catheter. This report describes and analyzes the use of lock therapy with intracatheter liposomal amphotericin B in a clinical case of fungal peritonitis.
View Article and Find Full Text PDFGels
January 2025
Department of Biotechnology, M S Ramaiah Institute of Technology, Bengaluru 560054, Karnataka, India.
forms a gel-like biofilm in the Foley's catheter (FC) causing tenacious biofouling and severe urinary tract infections (UTIs). For the first time, a spice extract-based antifungal lock therapy (ALT) has been developed to inhibit the gel matrix in FC. Aqueous extracts of garlic, clove, and Indian gooseberry were used as ALT lock solutions and tested against biofilm-forming multidrug-resistant clinical isolates of .
View Article and Find Full Text PDF, a member of the Erwiniaceae family, is a rarely reported human pathogen primarily associated with plants. This study presents a documented case of catheter-related bloodstream infection caused by in a 60-year-old female receiving home parenteral nutrition. Despite presenting with only minor clinical symptoms, blood cultures from both central and peripheral sites confirmed the presence of , identified by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) and whole-genome sequencing.
View Article and Find Full Text PDFInt J Artif Organs
January 2025
Konya Şehir Hastanesi, Konya, Turkey.
Background: Bleeding and thrombotic occlusion are complications of Central venous catheters. When selecting a catheter lock solution, factors such as bleeding, thrombotic occlusion, infection, and cost-effectiveness must be considered.
Methods: The study included 35 patients who used heparin as a locking solution and 35 patients who used 0.
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