AI Article Synopsis
- Researchers successfully developed a method for defluoroborylating polyfluoroarenes using photoredox catalysis at room temperature.
- The process involves generating a boryl radical through a single-electron transfer (SET) and shows high regioselectivity and functional group tolerance.
- Both computational and experimental approaches were utilized to better understand the reaction mechanism behind this innovative technique.
Article Abstract
The first photoredox-catalyzed defluoroborylation of polyfluoroarenes with NHC-BH has been facilely achieved at room temperature via a single-electron-transfer (SET)/radical addition pathway. This new strategy makes full use of the advantage of photoredox catalysis to generate the key boryl radical via direct activation of a B-H bond. Good functional group tolerance and high regioselectivity offer this protocol incomparable advantages in preparing a wide array of valuable polyfluoroarylboron compounds. Moreover, both computational and experimental studies were performed to illustrate the reaction mechanism.
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| http://dx.doi.org/10.1021/acs.orglett.0c00020 | DOI Listing |
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