Pb is a xenobiotic metal ion that competes for Ca-binding sites in proteins. Using the peripheral Ca-sensing domains of Syt1, we show that the chelating pH buffer Bis-Tris enables identification and functional characterization of high-affinity Pb sites that are likely to be targeted by bioavailable Pb.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7357838 | PMC |
| http://dx.doi.org/10.1039/d0mt00002g | DOI Listing |
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