AI Article Synopsis
- The study investigates the link between perinatal sentinel events (PSE) and MRI/neurodevelopmental outcomes in newborns with hypoxic-ischemic encephalopathy (HIE) receiving therapeutic hypothermia (TH).
- Out of 182 neonates analyzed, those with PSE showed a higher percentage of normal MRIs and better motor and language outcomes compared to those without PSE.
- The findings indicate that neonates with PSE experienced less severe brain injury and improved developmental outcomes at 18-36 months after TH treatment.
Article Abstract
Objective: To study the association between perinatal sentinel events (PSE) and brain MRI/neurodevelopmental outcomes in neonates with hypoxic-ischemic encephalopathy (HIE) receiving therapeutic hypothermia (TH).
Design: This is a retrospective single-center study. Data collection included perinatal history, brain MRI, and neurodevelopmental outcome.
Results: Out of the 182 neonates, 53 (29%) neonates had PSE and 129 (71%) neonates did not have PSE. Neonates with PSE had more normal MRIs (76%) compared with neonates without PSE (55%), p = 0.01. PSE was associated with favorable motor (p = 0.02), language outcome (p = 0.03), and trend to better cognitive scores (p = 0.13). In PSE, favorable motor outcome persisted (OR for impairment 0.15 (0.003-0.84), p = 0.03) after adjusting for the degree of encephalopathy and brain MRI injury. Injury on brain MRI despite TH after PSE was associated with unfavorable neurodevelopmental outcome (p < 0.001).
Conclusion: Neonates with HIE receiving TH after PSE had less severe injury on brain MRI after rewarming, and improved motor and language outcomes at 18-36 months.
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| http://dx.doi.org/10.1038/s41372-020-0602-8 | DOI Listing |
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