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Advance guide signs for exit ramps along urban expressways are increasingly critical, enhancing safety and mobility by improving the flow of vehicles exiting urban expressways. However, research has devoted scant attention to advance guide signs for exit ramps. This study aimed to identify and propose optimal design alternatives for exit ramp advance guide signs for different types of exit spacing. This study conducted a driving simulation experiment consisting of five design alternatives of advance guide signs and two exit ramp spacing variation. Eight indicators were measured. The repeated-measure analysis of variances (ANOVA) and the Technique for Order of Preference by Similarity to Ideal Solution (TOPSIS) were performed for the influence analysis and efficiency evaluation of different schemes. Influence analysis results showed better design alternatives in five schemes of advance guide signs, enabling drivers to more easily locate destination exits and change lanes fewer times, in addition to reducing drivers' need to decelerate, and improving traffic flow in the key influence range of destination exit ramps. The percentage of drivers successfully locating the destination exits also increased with optimal design alternatives of advance guide signs. When the exit ramp spacing tightened, on the other hand, drivers had to make more lane changes and accelerate and decelerate more frequently in the key influence range. As a result, a lower percentage of drivers successfully located destination exits. Efficiency evaluation results were also obtained. In tight spacing, three advance guide signs are recommended to be placed at 1 km, 0.5 km and 0 km prior to the beginning of the tapered deceleration lane. If conditions are limited, at least two advance guide signs should be used. With greater spacing, four advance guide signs are recommended, located at 2 km, 1 km, 0.5 km, and 0 km prior to the beginning of the tapered deceleration lane. If road conditions are limited, three advance guide signs should be used.
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http://dx.doi.org/10.1016/j.aap.2020.105465 | DOI Listing |
J Dance Med Sci
December 2024
Children's Hospital Los Angeles, Keck School of Medicine of USC, Los Angeles, CA, USA.
As demanding as dancing en pointe is, no universal standard exists to determine when a ballet dancer is ready to advance to this next level. The goal of this study was to provide preliminarily tested and reliable guidelines for a screening tool that can be used to determine (1) if a dancer is ready for pointe, (2) reasons why a dancer may not be ready, and (3) areas for improvement to guide training and preparation. Seventeen dancers aged 9 to 17 years with a minimum 4 years of ballet and who were either possibly ready for pointe or had been in pointe class less than 3 months participated in this study.
View Article and Find Full Text PDFJ Dermatol
December 2024
Department of Dermatology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Phasing, the process of determining which alleles at different loci on homologous chromosomes belong together on the same chromosome, is crucial in the diagnosis and management of autosomal recessive diseases. Advances in long-read sequencing technologies have significantly enhanced our ability to accurately determine haplotypes. This review discusses the application of low-coverage long-read sequencing, nanopore Cas9-guided long-read sequencing, and adaptive sampling in phasing, highlighting their utility in complex clinical scenarios.
View Article and Find Full Text PDFInt J Dev Biol
December 2024
Key Laboratory of Evolution & Marine Biodiversity (Ministry of Education) and Institute of Evolution and Marine Biodiversity, Ocean University of China, Qingdao, China.
The axolotl, a legendary creature with the potential to regenerate complex body parts, is positioned as a powerful model organism due to its extraordinary regenerative capabilities. Axolotl can undergo successful regeneration of multiple structures, providing us with the opportunity to understand the factors that exhibit altered activity between regenerative and non-regenerative animals. This comprehensive review will explore the mysteries of axolotl regeneration, from the initial cellular triggers to the intricate signaling cascades that guide this complex process.
View Article and Find Full Text PDFFront Pharmacol
December 2024
Faculty of General Medicine, Yaroslavl State Medical University, Yaroslavl, Russia.
Background And Objective: Dental implant therapy faces challenges in patients with Type 1 and Type 2 Diabetes Mellitus (T1DM and T2DM) due to adverse effects on bone metabolism and immune response. Despite advancements, diabetic patients face higher risks of peri-implantitis and compromised osseointegration. This review assesses the impact of anti-diabetic medications on implant outcomes, offering insights to bridge the gap between animal studies and clinical practice.
View Article and Find Full Text PDFProstate Cancer
December 2024
Division of Hematology and Medical Oncology, Department of Internal Medicine, Saint Louis University School of Medicine, St. Louis, Missouri, USA.
Assessment of comorbid diseases is essential to clinical research and may risk-stratify patients for mortality independent of established methods such as the Charlson Comorbidity Index (CCI). In a retrospective study of U.S.
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