Background: Intracranial fibrosarcoma is an extremely rare neoplasm in the central nervous system. Insofar there were only sporadic case reports describing its features. The purpose of this study is to review the clinical and surgical features of cases who were treated in our department.
Method: The authors retrospectively reviewed and detailed the clinical and surgical data obtained from 5 patients with fibrosarcoma who underwent treatment at our institute between January 2009 and January 2019.
Results: There were 3 males and 2 females including 2 juvenile and 3 senior patients. The most frequent sign was intermittent pain and vomiting. The location of the tumor included middle fossa, thalamus and midbrain, sellar and suprasellar region and right parietal-occipital lobe. Surgical observation demonstrated the consistency of the tumor was tenacious with abundant blood supply. Gross total resection was achieved in 2 cases. Pathological analysis showed spindle cells in a herringbone form with positive Vimentin staining in all 5 cases, with the absence of GFAP or S-100. All 5 patients were deceased eventually after a varied period of time after the first surgery.
Conclusion: Intracranial fibrosarcoma was a highly malignant entity presented in the central nervous system. Surgery still remains the first-line treatment followed by radiotherapy, however, the prognostic outcome was very poor. Future studies should be more focused on accumulation of the relevant information on this disease thus hopefully in assisting to developing more optimized treatment.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1097/SCS.0000000000006224 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Primary intracranial dedifferentiated liposarcoma: An extremely rare site with unusual histopathological findings.
Neuropathology
November 2024
Consultant histopathologist, Department of Pathology, Agilus Diagnostics Ltd, Fortis Memorial Research Institute, Gurugram, India.
Primary intracranial sarcomas constitute a rare group of tumors, with the most common types described in the literature being chondrosarcoma and fibrosarcoma. Dedifferentiated liposarcoma (DDLS) is a high-grade sarcoma that sometimes metastasizes to the brain. However, a primary intracranial DDLS is exceedingly rare.
View Article and Find Full Text PDFSclerosing epithelioid fibrosarcoma: a new mesenchymal non-meningothelial tumor involving the central nervous system?
Virchows Arch
June 2024
Department of Pathology, Strasbourg University Hospital, 67098, Strasbourg Cedex, France.
Article Synopsis
- Sclerosing epithelioid fibrosarcoma (SEF) is a rare type of cancer characterized by specific cell arrangements and unique traits, including a distinct immunohistochemical pattern and gene rearrangements involving EWSR1 and CREB3L genes.
- Although typically found in deep soft tissues, SEF can also occur in bones and other organs; however, this report highlights a rare case of SEF originating in the brain, specifically the left occipital region.
- The study discusses the necessary differential diagnoses for brain tumors and provides a detailed genetic and epigenetic comparison of this brain tumor to more common systemic cases of SEF.
Intracranial hemorrhage caused by dabrafenib and trametinib therapy for metastatic melanoma.
Melanoma Res
June 2024
Department of Dermatology, University Hospital, Inserm 1098.
Article Synopsis
- Molecular targeted therapy for metastatic melanoma is generally safer than chemotherapy but can still cause serious side effects, including life-threatening toxicity.
- A case study is reported where a patient treated with dabrafenib and trametinib experienced intracranial hemorrhage.
- Physicians need to be vigilant about this rare complication, ensuring the source of bleeding is correctly identified, as it may indicate new melanoma metastasis, anticoagulation overdose, or uncontrolled high blood pressure.
Surgical Treatment of Malignant Peripheral Nerve Sheath Tumor of the Scalp With Intracranial and Extracranial Extension: A Rare Case Report.
Ann Plast Surg
January 2024
From the Department of Orthopedic Surgery.
Malignant peripheral nerve sheath tumors of the scalp are rare neoplasms of the peripheral nervous system. Here, we describe an unusual malignant peripheral nerve sheath tumor of the scalp in an 84-year-old Asian man. The tumor was associated with bony destruction, intracranial, and extracranial extension.
View Article and Find Full Text PDFIntracranial Relapse in Pediatric Sarcoma.
J Pediatr Hematol Oncol
October 2023
Pediatric Hematology and Oncology, Cook Children's Medical Center, Fort Worth, TX.
Advances in local control techniques, chemotherapy regimens, and imaging modalities have led to improvements in both morbidity and mortality in pediatric sarcoma patients. However, approximately one-third of patients develop disease relapse and intracranial metastasis was considered rare. The incidence of sarcoma brain metastasis is thought to have increased and is associated with grim outcomes.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!