Good Fences Make Good Neighbors: Crumbs Regulates Rho-Kinase Dynamics to Assemble a Tissue Boundary.

Dev Cell

Department of Biology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address:

Published: February 2020

Boundary formation between nascent tissues prevents cell mixing, powering morphogenesis. In this issue of Developmental Cell, Sidor et al. (2020) describe a novel mechanism whereby the homophilic adhesion protein Crumbs regulates planar-polarized assembly of actomyosin cables at tissue boundaries by affecting dynamics of membrane recruitment of the myosin regulator Rho-kinase.

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http://dx.doi.org/10.1016/j.devcel.2020.01.018DOI Listing

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