In a paper titled "Responsive feedback: Towards a new paradigm to enhance intervention effectiveness", Viswanath . argue that dominant models of intervention design do not account for the complexity and unpredictability of implementation challenges. Particularly in the behavioural sciences, intervention designs need to consider many factors that will be uncertain, or unknown, at the beginning of a new project. This letter describes how we were able to respond to feedback during the design phase of a proof-of-concept project to create a digital service business for Nigerian patent and proprietary medicine vendors (PPMVs). Our approach was to create an initial 'Theory of Change' (ToC) based on a similar project with Kenyan shopkeepers. This ToC was revised following user feedback and a landscape analysis with key stakeholders. The new ToC required us to access additional funding to create a 'digital ordering' facility for the PPMVs. Digital ordering provides a mechanism whereby we can reduce the prevalence of counterfeit medicines, offer the PPMVs credit and group-buying facilities, and reduce supply chain costs through co-distribution with fast-moving consumer goods. An important learning point was that while our focus was on designing a platform to meet users' needs, changes in regulation meant that we spent considerably more time than anticipated meeting the needs of multiple stakeholders. However, the importance of ensuring stakeholders' continued buy-in cannot be underestimated and has likely increased the sustainability of the project in the longer term. As Viswanath . suggest, for responsive approaches to be widely adopted needs more flexibility than exists in current funding models and project plans. Both funding bodies and grantees will need to be more responsive to feedback coming from the field.
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http://dx.doi.org/10.12688/gatesopenres.13028.1 | DOI Listing |
PLoS One
January 2025
MAP Centre for Urban Health Solutions, St. Michael's Hospital Toronto, Toronto, Ontario, Canada.
Background: Latina women in the United States experience intimate partner violence (IPV) at high rates, but evidence suggests Latinas seek help for IPV at lower rates than other communities. Safety planning is an approach that provides those experiencing IPV with concrete actions to increase their safety and referrals to formal services. While safety planning is shown to reduce future incidences of violence, little is known about the safety planning priorities of Latinas.
View Article and Find Full Text PDFJ Cogn Neurosci
January 2025
Shahid Beheshti University, Tehran, Iran.
Risk-taking is a prominent aspect of adolescent behavior. A recent neurodevelopmental model suggests that this trait could influence prosocial and antisocial decision-making, proposing a new category known as prosocial and antisocial risk-taking. The primary objective of this study was to examine the electrophysiological underpinnings of prosocial and antisocial risk-taking in adolescence, a developmental period characterized by elevated risky, prosocial, and antisocial decisions.
View Article and Find Full Text PDFSci Immunol
January 2025
Laboratory of Molecular Immunology and Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health (NIH), Bethesda, MD 20892, USA.
Thymic stromal lymphopoietin (TSLP) is a type I cytokine that promotes allergic responses and mediates type 2 immunity. A balance between effector T cells (T), which drive the immune response, and regulatory T cells (T), which suppress the response, is required for proper immune homeostasis. Here, we report that TSLP differentially acts on T versus T to balance type 2 immunity.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
January 2025
Department of Entomology, University of California, Riverside, CA 92521.
Female mosquitoes require a vertebrate blood meal to activate reproduction, transmitting numerous devastating human diseases. Vitellogenesis is a central event of female reproduction that involves the massive production of vitellogenin (Vg) in the fat body and the maturation of ovaries. This process is controlled by the steroid hormone 20-hydroxyecdysone (20E); however, its molecular regulatory basis remains not completely understood.
View Article and Find Full Text PDFStrahlenther Onkol
January 2025
Department of Radiation Oncology, University Hospital, LMU Munich, Marchioninistr. 15, 81377, Munich, Germany.
Background: This study aims to evaluate the capabilities and limitations of large language models (LLMs) for providing patient education for men undergoing radiotherapy for localized prostate cancer, incorporating assessments from both clinicians and patients.
Methods: Six questions about definitive radiotherapy for prostate cancer were designed based on common patient inquiries. These questions were presented to different LLMs [ChatGPT‑4, ChatGPT-4o (both OpenAI Inc.
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