Background: Despite a substantial scientific progress over the past two decades, malaria continues to be a worldwide burden. Evergrowing resistance towards the currently available antimalarial drugs is a challenge to combat malaria. Medicinal plants are a promising source of new drugs to tackle this problem. Thus, the present study aimed at evaluating the antiplasmodial activity of in infected mice.
Methods: A 4-day suppressive test was employed to evaluate the antimalarial effect of 80% methanol and aqueous bark extracts of against in Swiss albino mice.
Results: The acute toxicity test indicated that both extracts of against < 0.001) compared to negative control. The maximum level of chemosuppression (60.2%) was exhibited at 400 mg/kg dose of 80% methanol extract. Moreover, the 80% methanol extract showed a significant ( < 0.001) compared to negative control. The maximum level of chemosuppression (60.2%) was exhibited at 400 mg/kg dose of 80% methanol extract. Moreover, the 80% methanol extract showed a significant (.
Conclusion: The present study indicated that hydromethanolic and aqueous bark extracts of possess a promising antimalarial activity, with higher effect exhibited by the hydromethanolic extract. against.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7001668 | PMC |
| http://dx.doi.org/10.1155/2020/9749410 | DOI Listing |
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