is associated with the development of high-risk neuroblastoma patients. Particularly, the expression of full length (FL) isoform, FL , correlates to high-risk neuroblastoma development and its inhibition is sufficient to induce neuroblastoma cells towards a worst phenotype. Here we have investigated the mechanisms of FL in neuroblastoma cell lines depleted for FL expression. We have shown that FL expression protects the cells from spontaneous DNA damage and from damage accumulated after irradiation. We demonstrated a role for FL as tumor suppressor to prevent unscheduled mitotic entry of DNA damaged cells and to lead to death cells that have bypassed cell cycle checkpoints. FL -depleted cells that have survived to checkpoints acquire features of aggressiveness. Overall, our results show that FL may defend cells against cancer and prevent malignant transformation of cells.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6995383 | PMC |
| http://dx.doi.org/10.7150/jca.36164 | DOI Listing |
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