Infections by multidrug-resistant (MDR) Gram-negative organisms (GN) are associated with a high mortality rate and present an increasing challenge to the healthcare system worldwide. In recent years, increasing evidence supports the association between the healthcare environment and transmission of MDRGN to patients and healthcare workers. To better understand the role of the environment in transmission and acquisition of MDRGN, we conducted a utilitarian review based on literature published from 2014 until 2019.
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http://dx.doi.org/10.1186/s13756-020-0685-1 | DOI Listing |
Nat Commun
January 2025
Department of Microbiology and Immunology, Wake Forest School of Medicine, Winston Salem, NC, USA.
Microbial species must compete for space and nutrients to persist in the gastrointestinal (GI) tract, and our understanding of the complex pathobiont-microbiota interactions is far from complete. Klebsiella pneumoniae, a problematic, often drug-resistant nosocomial pathogen, can colonize the GI tract asymptomatically, serving as an infection reservoir. To provide insight on how K.
View Article and Find Full Text PDFJ Hosp Infect
January 2025
HCAI/AMR Modelling and Evaluations Team, UK Health Security Agency, London, UK.
Introduction: Healthcare-associated infections result in worse outcomes for patients and greater financial burden. An estimated 4.8 million HCAIs occurred in hospitals across Europe in 2022-23.
View Article and Find Full Text PDFPLoS One
January 2025
School of Earth and Environmental Sciences, Seoul National University, Seoul, South Korea.
The oxidation states of vanadium determine its mobility and toxicity, and dissimilatory vanadate reduction has been reported in several microorganisms, highlighting the potential significance of this pathway in the remediation of vanadium contamination and the biogeochemical cycle. However, to date, most known microorganisms capable of reducing vanadate are Gram-negative respiratory bacteria belonging to the phylum Proteobacteria. In this study, we isolated Tepidibacter mesophilus strain VROV1 from deep-sea sediments on the northern Central Indian Ridge and investigated its ability to reduce vanadium and the impact of vanadate on its cellular metabolism.
View Article and Find Full Text PDFJ Clin Microbiol
January 2025
Department of Pathology, Harbor-UCLA Medical Center, Torrance, California, USA.
The complex (BCC) is a group of Gram-negative bacteria that cause opportunistic infections, most notably in people with cystic fibrosis (CF), and have been associated with outbreaks caused by contaminated medical products. Antimicrobial susceptibility testing (AST) is often used to guide treatment for BCC infections, perhaps most importantly in people with CF who are being considered for lung transplant. However, recent studies have highlighted problems with AST methods.
View Article and Find Full Text PDFMicrobiol Spectr
January 2025
Department of Microbiology, Anatomy, Physiology, and Pharmacology, La Trobe University, Melbourne, Victoria, Australia.
Bacterial membrane vesicles (MVs) are produced by all bacteria and contribute to numerous bacterial functions due to their ability to package and transfer bacterial cargo. In doing so, MVs have been shown to facilitate horizontal gene transfer, mediate antimicrobial activity, and promote biofilm formation. Uropathogenic is a pathogenic Gram-negative organism that persists in the urinary tract of its host due to its ability to form persistent, antibiotic-resistant biofilms.
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