AI Article Synopsis
- The study investigates how increased body fat might relate to more severe forms of breast cancer, focusing on the roles of specific proteins called adipokines, particularly leptin and adiponectin, and their receptors.
- Researchers analyzed breast tumor samples from 720 women, predominantly Black, using immunohistochemistry to measure the expression of these proteins and linked this data to the aggressiveness of the tumors based on various clinical factors.
- Results indicate that lower levels of leptin receptor expression in tumors were associated with more aggressive cancer types, especially in ER-negative and triple-negative breast cancers, suggesting a potential mechanism for the variations seen in tumor characteristics among individuals.
Article Abstract
Background: The molecular mechanisms underlying the association between increased adiposity and aggressive breast cancer phenotypes remain unclear, but likely involve the adipokines, leptin (LEP) and adiponectin (ADIPOQ), and their receptors (LEPR, ADIPOR1, ADIPOR2).
Methods: We used immunohistochemistry (IHC) to assess LEP, LEPR, ADIPOQ, ADIPOR1, and ADIPOR2 expression in breast tumor tissue microarrays among a sample of 720 women recently diagnosed with breast cancer (540 of whom self-identified as Black). We scored IHC expression quantitatively, using digital pathology analysis. We abstracted data on tumor grade, tumor size, tumor stage, lymph node status, Ki67, estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) from pathology records, and used ER, PR, and HER2 expression data to classify breast cancer subtype. We used multivariable mixed effects models to estimate associations of IHC expression with tumor clinicopathology, in the overall sample and separately among Blacks.
Results: Larger proportions of Black than White women were overweight or obese and had more aggressive tumor features. Older age, Black race, postmenopausal status, and higher body mass index were associated with higher LEPR IHC expression. In multivariable models, lower LEPR IHC expression was associated with ER-negative status and triple-negative subtype (P < 0.0001) in the overall sample and among Black women only. LEP, ADIPOQ, ADIPOR1, and ADIPOR2 IHC expression were not significantly associated with breast tumor clinicopathology.
Conclusions: Lower LEPR IHC expression within the breast tumor microenvironment might contribute mechanistically to inter-individual variation in aggressive breast cancer clinicopathology, particularly ER-negative status and triple-negative subtype.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7014630 | PMC |
| http://dx.doi.org/10.1186/s13058-020-1256-3 | DOI Listing |
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