A cobalt(II)-catalyzed [4+2] annulation of picolinamides with alkynes via C-H bond activation has been developed. The operationally simple annulation reaction allows for the synthesis of acyl-substituted 1H-benzoquinoline bearing multiple aromatic rings (up to 96 % yield) without co-oxidant or other oxidation factors under mild conditions. Several control experiments were carried out. This practical [4+2] annulation provides an efficient route to access highly functionalized compounds.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/chem.202000411 | DOI Listing |
Publication Analysis
Top Keywords
[4+2] annulation
12
cobaltii-catalyzed [4+2]
8
annulation picolinamides
8
picolinamides alkynes
8
alkynes c-h
8
c-h bond
8
bond activation
8
annulation
4
activation cobaltii-catalyzed
4
activation developed
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!