Graphene oxide (GO) was first modified to amine functionalized GO (AGO) and acts as a cationic polyelectrolyte. Chitosan (CS) was conjugated with folic acid (FA) through N, N´ -Dicyclohexylcarbodiimide coupling to form FA-CS. After this, itaconic acid and acrylic acid monomers are grafted to the hydroxyl group of CS using ethyleneglycol dimethacrylate as cross linker and potassium peroxydisulfate as an initiator to generate -COOH functional groups and forming chemically modified chitosan (CMCS). Further doxorubicin (DOX) loaded into the FA-CMCS/AGO through π-π stacking interactions. The resulting nanocomposite was characterized by FTIR, SEM, TEM, Raman, AFM, DLS and ZP. The drug loading capacity was as high as 95.0% and the drug release rate at pH 5.3 was significantly higher than that under physiological conditions of pH 7.4. Cell viability of L929, HeLa and MCF7 cells was studied. The studies suggest the drug carrier has potential clinical applications for anticancer drug delivery.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.ijbiomac.2020.02.053 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Eco-friendly synthesis of a porous reduced graphene oxide-polypyrrole-gold nanoparticle hybrid nanocomposite for electrochemical detection of methotrexate using a strip sensor.
Nanoscale
January 2025
Department of Chemistry, Indian Institute of Technology Palakkad, Palakkad, Kerala 678 557, India.
Chemotherapy is a crucial cancer treatment, but its effectiveness requires precise monitoring of drug concentrations in patients. This study introduces an innovative electrochemical strip sensor design to detect and continuously monitor methotrexate (MTX), a key chemotherapeutic drug. The sensor is crafted through an eco-friendly synthesis process that produces porous reduced graphene oxide (PrGO), which is then integrated with gold nanocomposites and polypyrrole (PPy) to boost the performance of a screen-printed carbon electrode (SPCE).
View Article and Find Full Text PDFVolatile Sieving Using Architecturally Designed Nanochannel Lamellar Membranes in Membrane Desalination.
ACS Nano
January 2025
Key Laboratory of New Membrane Materials, Ministry of Industry and Information Technology, School of Environmental and Biological Engineering, Nanjing University of Science and Technology, Nanjing 210094, P. R. China.
Thermally driven membrane desalination processes have garnered significant interest for their potential in the treatment of hypersaline wastewater. However, achieving high rejection rates for volatiles while maintaining a high water flux remains a considerable challenge. Herein, we propose a thermo-osmosis-evaporation (TOE) system that utilizes molecular intercalation-regulated graphene oxide (GO) as the thermo-osmotic selective permeation layer, positioned on a hydrophobic poly(vinylidene fluoride) fibrous membrane serving as the thermo-evaporation layer.
View Article and Find Full Text PDFDifferential insulin response characteristics of graphene oxide-gold nanoparticle composites under varied synthesis conditions.
PLoS One
January 2025
Key Laboratory of Clinical Evaluation Technology for Medical Device of Zhejiang Province, Department of Clinical Engineering and Material Supplies, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, P.R. China.
The structural alterations in the constituent materials of nanocomposites such as graphene nanocomposites typically induce changes in their properties including mechanical, electrical, and optical properties. Therefore, by altering the preparation conditions of nanocomposites and investigating their responsiveness to basic biomolecules (such as proteins), it is possible to explore the application potentials of the composites and guide development of new nanocomposite preparation. In this study, different composites of graphene oxide and gold nanoparticles (AuNPs/GO) were obtained by varying the volumes of reducing agents used in the one-pot hydrothermal method.
View Article and Find Full Text PDFEnhancing CO Oversaturation in the Confined Water Enables Superior Gas Selectivity of 2D Membranes.
J Phys Chem Lett
January 2025
Haihe Laboratory of Sustainable Chemical Transformations, Tianjin 300192, China.
Due to the global demands on carbon neutralization, CO separation membranes, particularly those based on two-dimensional (2D) materials, have attracted increasing attention. However, recent works have focused on the chemical decoration of membranes to realize the selective transport, leading to the compromised stability in the presence of moisture. Herein, we develop a series of 2D capillaries based on layered double hydroxide (LDH), graphene oxide, and vermiculite to enhance the oversaturation of CO in the confined water for promoting the membrane permselectivity.
View Article and Find Full Text PDFEnhanced detection of Brain-Derived Neurotrophic Factor (BDNF) using a reduced graphene oxide field-effect transistor aptasensor.
Nanoscale
January 2025
James Watt School of Engineering, University of Glasgow, Glasgow G12 8QQ, UK.
Neurodegenerative diseases, characterized by the progressive deterioration of neuronal function and structure, pose significant global public health and economic challenges. Brain-Derived Neurotrophic Factor (BDNF), a key regulator of neuroplasticity and neuronal survival, has emerged as a critical biomarker for various neurodegenerative and psychiatric disorders, including Alzheimer's disease. Traditional diagnostic methods, such as Enzyme-Linked Immunosorbent Assay (ELISA) and electrochemiluminescence (ECL) assays, face limitations in terms of sensitivity, stability, reproducibility, and cost-effectiveness.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!