AI Article Synopsis
- Paraoxonase-2 plays a key role in controlling reactive oxygen species in mitochondria, suggesting it is a target for therapies aimed at diseases linked to oxidative stress.
- The anti-diabetic medication pioglitazone may offer protective benefits for neurodegenerative diseases and brain injuries, although the exact mechanisms behind this effect are not fully understood.
- Research shows that administering pioglitazone at a specific dose for five days significantly boosts paraoxonase-2 levels in the mouse striatum, indicating its potential utility in exploring neuroprotection in the brain.
Article Abstract
Paraoxonase-2 regulates reactive oxygen species production in mitochondria. Stimulating its expression has therapeutic potential for diseases where oxidative stress plays a significant role in the pathology. Evidence suggests that the anti-diabetic drug pioglitazone may provide neuroprotection in Parkinson's disease, Alzheimer's disease, brain trauma and ischemia, but the biochemical pathway(s) responsible has not been fully elucidated. Here we report that pioglitazone (10 mg/kg/day) for 5 days significantly increased paraoxonase-2 expression in mouse striatum. Thus, this result highlights paraoxonase-2 as a target for neuroprotective strategies and identifies pioglitazone as a tool to study the role of paraoxonase-2 in brain.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7089823 | PMC |
| http://dx.doi.org/10.1016/j.expneurol.2020.113234 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Altered Levels of Gene Expression of Drug Metabolism Enzymes in Rat Brain Following Kainic Acid Treatment.
Turk J Pharm Sci
September 2024
Ege University Faculty of Medicine, Department of Physiology, İzmir, Türkiye.
Objectives: Previous studies have shown that gene expressions can be regulated in the hippocampus of rats after seizures induced by kainic acid (KA). The aim of this study was to examine the potential regulatory impact of KA administration on gene expression levels of enzymes responsible for drug metabolism in rat hippocampal tissue.
Materials And Methods: Rats received intraperitoneal injections of KA and saline at a dose of 10 mg/kg.
Corinthian Currants Promote the Expression of Paraoxonase-1 and Enhance the Antioxidant Status in Serum and Brain of 5xFAD Mouse Model of Alzheimer's Disease.
Biomolecules
April 2024
Institute of Biosciences and Applications, National Center for Scientific Research "Demokritos", Agia Paraskevi, 15341 Athens, Greece.
Paraoxonase-1 (PON1), a serum antioxidant enzyme, has been implicated in Alzheimer's disease (AD) pathogenesis that involves early oxidative damage. Corinthian currants and their components have been shown to display antioxidant and other neuroprotective effects in AD. We evaluated the effect of a Corinthian currant paste-supplemented diet (CurD), provided to 1-month-old 5xFAD mice for 1, 3, and 6 months, on PON1 activity and levels of oxidation markers in serum and the brain of mice as compared to a control diet (ConD) or glucose/fructose-matched diet (GFD).
View Article and Find Full Text PDFAdjunctive silymarin supplementation and its effects on disease severity, oxidative stress, and inflammation in patients with Alzheimer's disease.
Nutr Neurosci
October 2024
Regenerative Medicine Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Background: Brain tissue in Alzheimer's patients is exposed to oxidative stress. Silymarin is an adjunct drug that has anti-inflammatory and antioxidant properties.
Objective: This study aimed to evaluate the effect of silymarin on biomarkers of oxidative stress, inflammation, and disease severity in Alzheimer's patients.
Signature of paraoxonases in the altered redox homeostasis in Alzheimer's disease.
Chem Biol Interact
January 2024
Department of Life Sciences and Biotechnology and LTTA Centre, University of Ferrara, Italy; Psychiatric Department, School of Medicine, University of Maryland, Baltimore MD, USA. Electronic address:
Paraoxonase (PON) enzymes (PON1, PON2 and PON3) exert antioxidant properties through arylesterase, lactonase and paraoxonase activities. Increasing findings suggested their potential involvement, particularly PON1 and PON2, in Alzheimer's disease (AD), a neurodegenerative pathology characterized by early oxidative stress. Specifically, decreased serum PON1-arylesterase and lactonase activities seem to be associated with an increased brain oxidative damage in early AD, leading to hypothesize that PON activity alterations might be an early event in AD.
View Article and Find Full Text PDFCausal associations between COVID-19 and childhood mental disorders.
BMC Psychiatry
December 2023
Department of Psychiatry, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, 210029, China.
Background: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can invade both the peripheral and central nervous systems and impact the function of the brain. Therefore, it is necessary to evaluate the mutual influences between COVID-19 outcomes and childhood mental disorders.
Methods: We examined genetic correlations and potential causalities between three childhood mental disorders and three COVID-19 phenotypes by genetically proxied analyses.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!