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| http://dx.doi.org/10.1212/CPJ.0000000000000602 | DOI Listing |
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Successful treatment of recurrent refractory Kaposi's sarcoma in AIDS: a case report.
Front Oncol
December 2024
The Second Infectious Disease Department, Xixi Hospital of Hangzhou, Hangzhou, China.
Article Synopsis
- Kaposi's sarcoma (KS) is a soft tissue lesion linked to HHV-8 infection, often seen in immunocompromised patients, especially those with AIDS, and has a high mortality rate.
- A case report details a patient with AIDS-KS who relapsed after initial chemotherapy, but achieved complete remission with a PD-1 inhibitor, indicating its effectiveness in treatment.
- The PD-1 inhibitor was well-tolerated, improved the patient's immune system, and suggests a promising approach for managing AIDS-KS.
Clinical Characteristics and Risk Factors for Cryptococcal Meningitis in Diverse Patient Populations in New York City.
Open Forum Infect Dis
October 2024
Department of Neurology, Columbia University Irving Medical Center, New York, New York, USA.
Background: Cryptococcal meningitis (CM) is responsible for 15%-20% of human immunodeficiency virus (HIV)-associated mortalities. CM prevalence has also increased in other immunocompromised populations of transplant recipients, patients with cancer, and individuals on immunomodulatory medication.
Methods: This retrospective review included 51 definitive patients with CM hospitalized at a tertiary academic medical center in New York City between 2010 and 2023.
HIV-Associated Thrombotic Thrombocytopenic Purpura in a Virally Suppressed Patient With Normal CD4 Count: A Rare Presentation.
Cureus
September 2024
Hematology and Oncology, Charleston Area Medical Center, Charleston, USA.
Thrombotic thrombocytopenic purpura (TTP) is a thrombotic process characterized by multiorgan failure secondary to microvascular thrombi comprising platelets and von Willebrand factor. HIV is a known risk factor for TTP. However, patients generally have low CD4+ count during initial presentation or subsequent flare-ups.
View Article and Find Full Text PDFCROI 2024: Tuberculosis, Mpox, and Other Infectious Complications in People With HIV.
Top Antivir Med
July 2024
University of California San Francisco, San Francisco, California, USA.
Several novel antituberculosis agents, including long-acting injectable agents in mouse models, have shown promise in preclinical and early clinical studies. This encouraging news is offset by the failures of a tuberculosis (TB) vaccine to prevent disease recurrence and a 3-month clofazimine-based treatment regimen for drug-susceptible TB. Clinically focused insights regarding TB, mpox, and other HIV-associated infectious complications that were presented at the 2024 Conference on Retroviruses and Opportunistic Infections (CROI) are summarized in this review.
View Article and Find Full Text PDFCase Series of HIV-Associated Oral Lesions Across Different Clinical Stages in People Living with HIV.
HIV AIDS (Auckl)
July 2024
Department of Oral Medicine, Faculty of Dentistry, Universitas Padjadjaran, Bandung, Indonesia.
Article Synopsis
- HIV can cause oral mucosal lesions at any stage of infection, despite treatment advancements with highly active antiretroviral therapy (HAART).
- A study involved five patients with canker sores, revealing a variety of oral lesions associated with different HIV stages and highlighting risk factors like poor hygiene and low immune function.
- Treatment and care strategies, including improving oral hygiene and managing comorbidities, are important for addressing these lesions and enhancing overall health in people living with HIV.
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