AI Article Synopsis
- Age-related hearing loss (ARHL) occurs due to aging of the auditory system, primarily through cell death mechanisms like apoptosis induced by reactive oxygen species.
- The study aimed to investigate whether melatonin, known for its antioxidant properties, could help prevent outer hair cell dysfunction in a mouse model prone to ARHL.
- Results showed that mice treated with melatonin had significantly better auditory function than the control group after 10 months, indicating melatonin's protective effects against hearing loss.
Article Abstract
Introduction: Age-related hearing loss (ARHL) is a consequence of aging of the auditory system. The best known mechanism of cell death in ARHL is apoptosis due to increased production of reactive oxygen species. In this context, it is hypothesized that melatonin, owing to its high antioxidant potential and its action in the mitochondria, helps prevent or delay outer hair cell dysfunction (HCD).
Aims: To evaluate the effect of melatonin on the prevention of HCD dysfunction in the ARHL process in a susceptible murine C57BL/6J model.
Method: C57BL/6J animals were divided into two groups: control (CG) and melatonin (MG). The CG received a saline and ethanol solution and the MG, melatonin (10 mg/kg/day). The solutions were offered daily (50 μl) orally over a 10-month period. Distortion Product Otoacoustic Emissions (DPOAE) measurements were conducted once a month.
Results: There was a decrease in DPOAE values in both groups over time and a differentiation between them from the 10th month of life onwards. At 10 months, the MG maintained higher DPOAE values than the CG at all frequencies tested.
Conclusion: The use of melatonin has otoprotective effects on HCD in the ARHL process in the C57BL/6J model.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7010238 | PMC |
| http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0228943 | PLOS |
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