Oligonucleotides represent powerful DNA-recognition tools, but the formation of undesirable "self-duplexes" becomes more probable with increasing DNA affinity. Herein, we have developed a modified nucleobase with "self-avoiding" properties. Facile methylation of guanine yields a cationic N7-methylguanine, which suppresses the formation of self-duplexes whilst improving DNA affinity through electrostatic interaction.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1039/d0cc00169d | DOI Listing |
Publication Analysis
Top Keywords
dna affinity
12
cationic guanine
4
guanine positively
4
positively charged
4
charged nucleobase
4
nucleobase improved
4
improved dna
4
affinity inhibits
4
inhibits self-duplex
4
self-duplex formation
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!